| Preterm birth attenuates association between low birth weight and endothelial dysfunction. | |
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MedLine Citation:
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PMID: 12925463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Low birth weight predisposes to later coronary disease. To further elucidate the mechanisms behind this association and their timing, vascular endothelial function-a key factor in early pathophysiology of atherosclerosis-was studied in 54 infants born either before the third trimester or at term. METHODS AND RESULTS: All subjects were studied at 3 months of postnatal age. A laser-Doppler technique was used to measure skin perfusion before and after transdermal iontophoresis of acetylcholine (ACh; an endothelium-dependent vasodilator). In infants born at term (n=19; birth weight range: 2230 to 4205 g), maximum perfusion after ACh was 109+/-8 perfusion units (PU, mean+/-SEM) in normal-birth weight controls compared with 56+/-13 PU among those who had been small for gestational age at birth (P<0.01). In infants born preterm (n=35; birth weight range, 722 to 1868 g), ACh induced similar perfusion responses among subjects appropriate for gestational age (113+/-16 PU) and in those small for gestational age at birth (109+/-19 PU). CONCLUSIONS: Impairment in human endothelial function associated with low birth weight occurs or emerges late in pregnancy. Very preterm birth attenuates this association. Different gene-environment interactions in the third trimester may contribute to this finding. |
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Authors:
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Mikael Norman; Helena Martin |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2003-08-18 |
Journal Detail:
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Title: Circulation Volume: 108 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-26 Completed Date: 2003-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 996-1001 Citation Subset: AIM; IM |
Affiliation:
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Department of Women and Child Health, Karolinska Institute, Stockholm, Sweden. mikael.norman@ks.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Birth Weight Blood Pressure / physiology Endothelium, Vascular / drug effects, physiology*, physiopathology Female Gestational Age Humans Infant Infant, Low Birth Weight / physiology* Infant, Newborn Infant, Premature / physiology* Infant, Small for Gestational Age / physiology Infant, Very Low Birth Weight / physiology* Laser-Doppler Flowmetry Male Pregnancy Pregnancy Trimester, Third Reference Values Regional Blood Flow / drug effects Sex Factors Skin / blood supply Vasodilation / drug effects, physiology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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