Document Detail

Preterm birth attenuates association between low birth weight and endothelial dysfunction.
MedLine Citation:
PMID:  12925463     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Low birth weight predisposes to later coronary disease. To further elucidate the mechanisms behind this association and their timing, vascular endothelial function-a key factor in early pathophysiology of atherosclerosis-was studied in 54 infants born either before the third trimester or at term. METHODS AND RESULTS: All subjects were studied at 3 months of postnatal age. A laser-Doppler technique was used to measure skin perfusion before and after transdermal iontophoresis of acetylcholine (ACh; an endothelium-dependent vasodilator). In infants born at term (n=19; birth weight range: 2230 to 4205 g), maximum perfusion after ACh was 109+/-8 perfusion units (PU, mean+/-SEM) in normal-birth weight controls compared with 56+/-13 PU among those who had been small for gestational age at birth (P<0.01). In infants born preterm (n=35; birth weight range, 722 to 1868 g), ACh induced similar perfusion responses among subjects appropriate for gestational age (113+/-16 PU) and in those small for gestational age at birth (109+/-19 PU). CONCLUSIONS: Impairment in human endothelial function associated with low birth weight occurs or emerges late in pregnancy. Very preterm birth attenuates this association. Different gene-environment interactions in the third trimester may contribute to this finding.
Mikael Norman; Helena Martin
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-08-18
Journal Detail:
Title:  Circulation     Volume:  108     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-26     Completed Date:  2003-09-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  996-1001     Citation Subset:  AIM; IM    
Department of Women and Child Health, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Acetylcholine / pharmacology
Birth Weight
Blood Pressure / physiology
Endothelium, Vascular / drug effects,  physiology*,  physiopathology
Gestational Age
Infant, Low Birth Weight / physiology*
Infant, Newborn
Infant, Premature / physiology*
Infant, Small for Gestational Age / physiology
Infant, Very Low Birth Weight / physiology*
Laser-Doppler Flowmetry
Pregnancy Trimester, Third
Reference Values
Regional Blood Flow / drug effects
Sex Factors
Skin / blood supply
Vasodilation / drug effects,  physiology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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