Document Detail


Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function.
MedLine Citation:
PMID:  23224059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Preterm birth leads to an early switch from fetal to postnatal circulation before completion of left ventricular in utero development. In animal studies, this results in an adversely remodeled left ventricle. We determined whether preterm birth is associated with a distinct left ventricular structure and function in humans.
METHODS AND RESULTS: A total of 234 individuals 20 to 39 years of age underwent cardiovascular magnetic resonance. One hundred two had been followed prospectively since preterm birth (gestational age=30.3±2.5 week; birth weight=1.3±0.3 kg), and 132 were born at term to uncomplicated pregnancies. Longitudinal and short-axis cine images were used to quantify left ventricular mass, 3-dimensional geometric variation by creation of a unique computational cardiac atlas, and myocardial function. We then determined whether perinatal factors modify these left ventricular parameters. Individuals born preterm had increased left ventricular mass (66.5±10.9 versus 55.4±11.4 g/m(2); P<0.001) with greater prematurity associated with greater mass (r = -0.22, P=0.03). Preterm-born individuals had short left ventricles with small internal diameters and a displaced apex. Ejection fraction was preserved (P>0.99), but both longitudinal systolic (peak strain, strain rate, and velocity, P<0.001) and diastolic (peak strain rate and velocity, P<0.001) function and rotational (apical and basal peak systolic rotation rate, P =0.05 and P =0.006; net twist angle, P=0.02) movement were significantly reduced. A diagnosis of preeclampsia during the pregnancy was associated with further reductions in longitudinal peak systolic strain in the offspring (P=0.02, n=29).
CONCLUSIONS: Individuals born preterm have increased left ventricular mass in adult life. Furthermore, they exhibit a unique 3-dimensional left ventricular geometry and significant reductions in systolic and diastolic functional parameters.
CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01487824.
Authors:
Adam J Lewandowski; Daniel Augustine; Pablo Lamata; Esther F Davis; Merzaka Lazdam; Jane Francis; Kenny McCormick; Andrew R Wilkinson; Atul Singhal; Alan Lucas; Nic P Smith; Stefan Neubauer; Paul Leeson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-05
Journal Detail:
Title:  Circulation     Volume:  127     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-15     Completed Date:  2013-03-12     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-206     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01487824
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure
Cardiac Imaging Techniques
Diastole
Female
Follow-Up Studies
Humans
Hypertrophy, Left Ventricular / epidemiology*,  pathology*
Imaging, Three-Dimensional
Infant, Newborn
Infant, Premature*
Magnetic Resonance Imaging
Male
Prospective Studies
Risk Factors
Systole
Ventricular Dysfunction, Left / epidemiology*,  pathology*
Young Adult
Grant Support
ID/Acronym/Agency:
099973//Wellcome Trust; FS/06/024//British Heart Foundation; FS/11/65/28865//British Heart Foundation; //Medical Research Council
Comments/Corrections
Comment In:
Circulation. 2013 Jan 15;127(2):160-1   [PMID:  23224058 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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