Document Detail

Presynaptic regulation of neurotransmitter release in hypertension.
MedLine Citation:
PMID:  1680586     Owner:  NLM     Status:  MEDLINE    
1. The present review discusses evidence in support of the concept that alterations in sympathetic neurotransmitter release might contribute to the pathogenesis of hypertension. 2. Studies suggest that changes in sympathetic nervous activity in both the central and peripheral nervous systems participate in blood pressure control. 3. In the periphery increased release of norepinephrine from vascular adrenergic neurons might lead to the enhanced vasoconstrictor responses and thus to an elevation in systemic blood pressure. 4. The amount of neurotransmitter release from sympathetic nerve endings can be regulated by autoregulatory systems by presynaptic receptors located on nerve terminals. 5. It has been proposed that alterations to sympathetic nervous activity of hypertension might be partially due to abnormalities in presynaptic modulation of neurotransmitter release in central and peripheral tissues. 6. This article summarizes the results of studies to evaluate presynaptic receptor functions and sympathetic neurotransmitter release in hypertension.
K Tsuda; Y Masuyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  18     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-11-05     Completed Date:  1991-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  455-67     Citation Subset:  IM    
Department of Medicine, Wakayama Medical College, Japan.
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MeSH Terms
Catecholamines / physiology*
Hypertension / physiopathology*
Neurotransmitter Agents / secretion*
Synapses / physiology*
Reg. No./Substance:
0/Catecholamines; 0/Neurotransmitter Agents

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