| Presynaptic regulation of neurotransmitter release in hypertension. | |
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MedLine Citation:
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PMID: 1680586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The present review discusses evidence in support of the concept that alterations in sympathetic neurotransmitter release might contribute to the pathogenesis of hypertension. 2. Studies suggest that changes in sympathetic nervous activity in both the central and peripheral nervous systems participate in blood pressure control. 3. In the periphery increased release of norepinephrine from vascular adrenergic neurons might lead to the enhanced vasoconstrictor responses and thus to an elevation in systemic blood pressure. 4. The amount of neurotransmitter release from sympathetic nerve endings can be regulated by autoregulatory systems by presynaptic receptors located on nerve terminals. 5. It has been proposed that alterations to sympathetic nervous activity of hypertension might be partially due to abnormalities in presynaptic modulation of neurotransmitter release in central and peripheral tissues. 6. This article summarizes the results of studies to evaluate presynaptic receptor functions and sympathetic neurotransmitter release in hypertension. |
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Authors:
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K Tsuda; Y Masuyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 18 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-11-05 Completed Date: 1991-11-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 455-67 Citation Subset: IM |
Affiliation:
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Department of Medicine, Wakayama Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catecholamines / physiology* Humans Hypertension / physiopathology* Neurotransmitter Agents / secretion* Synapses / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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