Document Detail

Presynaptic kainate receptors in the hippocampus: slowly emerging from obscurity.
MedLine Citation:
PMID:  11719198     Owner:  NLM     Status:  MEDLINE    
Kainate receptor agonists depress transmitter release at several synapses in the hippocampus. Distinct mechanisms appear to underlie this phenomenon at different synapses. Recently, it has emerged that presynaptic kainate receptors can also potentiate the release of both GABA and glutamate and that axonal kainate receptors can trigger ectopic action potentials in interneurons. Because synaptically released glutamate mimics many of the actions of exogenous agonists, presynaptic kainate receptors potentially play an extensive role in hippocampal signaling.
D M Kullmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neuron     Volume:  32     ISSN:  0896-6273     ISO Abbreviation:  Neuron     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-23     Completed Date:  2002-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-4     Citation Subset:  IM    
Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom.
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MeSH Terms
Hippocampus / physiology*
Receptors, Kainic Acid / physiology*
Receptors, Presynaptic / physiology
Reg. No./Substance:
0/Receptors, Kainic Acid; 0/Receptors, Presynaptic

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