Document Detail


Presynaptic kainate receptor activation is a novel mechanism for target cell-specific short-term facilitation at Schaffer collateral synapses.
MedLine Citation:
PMID:  17050718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Target cell-specific differences in short-term plasticity have been attributed to differences in the initial release probability of synapses. Using GIN (GFP-expressing inhibitory neurons) transgenic mice that express enhanced green fluorescent protein (EGFP) in a subset of interneurons containing somatostatin, we show that Schaffer collateral synapses onto the EGFP-expressing somatostatin interneurons in CA1 have very large short-term facilitation, even larger facilitation than onto pyramidal cells, in contrast to the majority of interneurons that have little or no facilitation. Using a combination of electrophysiological recordings and mathematical modeling, we show that the large short-term facilitation is caused both by a very low initial release probability and by synaptic activation of presynaptic kainate receptors that increase release probability on subsequent stimuli. Thus, we have discovered a novel mechanism for target cell-specific short-term plasticity at Schaffer collateral synapses in which the activation of presynaptic kainate receptors by synaptically released glutamate contributes to large short-term facilitation, enabling selective enhancement of the inputs to a subset of interneurons.
Authors:
Hua Yu Sun; Lynn E Dobrunz
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  26     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-19     Completed Date:  2006-11-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10796-807     Citation Subset:  IM    
Affiliation:
Department of Neurobiology, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Excitatory Postsynaptic Potentials / physiology*
Hippocampus / physiology
Male
Mice
Mice, Transgenic
Pyramidal Cells / physiology
Reaction Time
Receptors, Kainic Acid / physiology*
Receptors, Presynaptic / physiology*
Synapses / physiology*
Synaptic Transmission / physiology*
Grant Support
ID/Acronym/Agency:
P01-HD38760/HD/NICHD NIH HHS; P30-HD38985/HD/NICHD NIH HHS; R01 MH65328/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Kainic Acid; 0/Receptors, Presynaptic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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