| Presynaptic involvement of nitric oxide in dopamine D1/D5 receptor-induced sustained enhancement of synaptic currents mediated by ionotropic glutamate receptors in the rat hippocampus. | |
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MedLine Citation:
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PMID: 10462104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using whole-cell patch-clamp recordings, the study tested the possibility whether nitric oxide (NO) was involved in dopamine D1/D5 receptor (D1/D5r)-induced sustained enhancement of excitatory postsynaptic currents (EPSCs) mediated by ionotropic glutamate receptors in rat hippocampal slices. Activation of D1/D5r by a selective agonist, 50 microM (+/-)-6-chloro-PB hydrobromide, elicited not only a sustained enhancement but also an increased frequency of spontaneous EPSC. The D1/D5r-induced effect was associated with decreases in paired-pulse facilitation (PPF). A selective inhibitor of neuronal NO synthase (nNOS), 100 microM 7-nitroindazole monosodium salt, substantially attenuated both the magnitudes of D1/D5r-induced enhancement and PPF decrease. These results suggest that presynaptic effects mediated by NO, possibly synthesized by nNOS, are involved in D1/D5-induced sustained enhancement of synaptic currents mediated by ionotropic glutamate receptors in the hippocampus. |
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Authors:
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S N Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 270 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-10-13 Completed Date: 1999-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 87-90 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, ROC. snyang@ndmc1.ndmctsgh.edu.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzazepines / pharmacology Dopamine Agonists / pharmacology Electric Stimulation Excitatory Postsynaptic Potentials / drug effects, physiology Hippocampus / drug effects, physiology* Indazoles / pharmacology Male Neuroprotective Agents / pharmacology Nitric Oxide / physiology* Patch-Clamp Techniques Presynaptic Terminals / physiology* Rats Rats, Sprague-Dawley Receptors, Dopamine / physiology* Receptors, Dopamine D1 / physiology Receptors, Dopamine D5 Receptors, Glutamate / physiology* Synapses / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Dopamine Agonists; 0/Drd5 protein, rat; 0/Indazoles; 0/Neuroprotective Agents; 0/Receptors, Dopamine; 0/Receptors, Dopamine D1; 0/Receptors, Glutamate; 10102-43-9/Nitric Oxide; 137750-35-7/Receptors, Dopamine D5; 2942-42-9/7-nitroindazole; 71636-61-8/SK&F 81297 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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