Document Detail


Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search.
MedLine Citation:
PMID:  21458672     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Internal physiological states influence behavioral decisions. We have investigated the underlying cellular and molecular mechanisms at the first olfactory synapse for starvation modulation of food-search behavior in Drosophila. We found that a local signal by short neuropeptide F (sNPF) and a global metabolic cue by insulin are integrated at specific odorant receptor neurons (ORNs) to modulate olfactory sensitivity. Results from two-photon calcium imaging show that starvation increases presynaptic activity via intraglomerular sNPF signaling. Expression of sNPF and its receptor (sNPFR1) in Or42b neurons is necessary for starvation-induced food-search behavior. Presynaptic facilitation in Or42b neurons is sufficient to mimic starvation-like behavior in fed flies. Furthermore, starvation elevates the transcription level of sNPFR1 but not that of sNPF, and insulin signaling suppresses sNPFR1 expression. Thus, starvation increases expression of sNPFR1 to change the odor map, resulting in more robust food-search behavior.
Authors:
Cory M Root; Kang I Ko; Amir Jafari; Jing W Wang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cell     Volume:  145     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-05-27     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arthropod Antennae / metabolism
Drosophila / physiology*
Drosophila Proteins / metabolism*
Female
Neuropeptides / metabolism*
Odors
Receptors, Neuropeptide / metabolism*
Receptors, Odorant / metabolism*
Sensory Receptor Cells / metabolism
Signal Transduction*
Starvation / metabolism
Synapses / metabolism
Grant Support
ID/Acronym/Agency:
1F31DC009511/DC/NIDCD NIH HHS; F31 DC009511-02/DC/NIDCD NIH HHS; R01 DC009597/DC/NIDCD NIH HHS; R01 DC009597-04/DC/NIDCD NIH HHS; R01 DK092640/DK/NIDDK NIH HHS; R01DC009597/DC/NIDCD NIH HHS; R21 DC010458/DC/NIDCD NIH HHS; R21 DC010458-02/DC/NIDCD NIH HHS; R21DC010458/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/NPFR1 protein, Drosophila; 0/Neuropeptides; 0/Receptors, Neuropeptide; 0/Receptors, Odorant; 142191-57-9/neuropeptide F
Comments/Corrections
Comment In:
Cell. 2011 Apr 1;145(1):17-8   [PMID:  21458663 ]

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