| Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search. | |
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MedLine Citation:
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PMID: 21458672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Internal physiological states influence behavioral decisions. We have investigated the underlying cellular and molecular mechanisms at the first olfactory synapse for starvation modulation of food-search behavior in Drosophila. We found that a local signal by short neuropeptide F (sNPF) and a global metabolic cue by insulin are integrated at specific odorant receptor neurons (ORNs) to modulate olfactory sensitivity. Results from two-photon calcium imaging show that starvation increases presynaptic activity via intraglomerular sNPF signaling. Expression of sNPF and its receptor (sNPFR1) in Or42b neurons is necessary for starvation-induced food-search behavior. Presynaptic facilitation in Or42b neurons is sufficient to mimic starvation-like behavior in fed flies. Furthermore, starvation elevates the transcription level of sNPFR1 but not that of sNPF, and insulin signaling suppresses sNPFR1 expression. Thus, starvation increases expression of sNPFR1 to change the odor map, resulting in more robust food-search behavior. |
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Authors:
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Cory M Root; Kang I Ko; Amir Jafari; Jing W Wang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Cell Volume: 145 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-05-27 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 133-44 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arthropod Antennae / metabolism Drosophila / physiology* Drosophila Proteins / metabolism* Female Neuropeptides / metabolism* Odors Receptors, Neuropeptide / metabolism* Receptors, Odorant / metabolism* Sensory Receptor Cells / metabolism Signal Transduction* Starvation / metabolism Synapses / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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1F31DC009511/DC/NIDCD NIH HHS; F31 DC009511-02/DC/NIDCD NIH HHS; R01 DC009597-04/DC/NIDCD NIH HHS; R01 DK092640/DK/NIDDK NIH HHS; R01DC009597/DC/NIDCD NIH HHS; R21 DC010458-02/DC/NIDCD NIH HHS; R21DC010458/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/NPFR1 protein, Drosophila; 0/Neuropeptides; 0/Receptors, Neuropeptide; 0/Receptors, Odorant; 142191-57-9/neuropeptide F |
| Comments/Corrections | |
Comment In:
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Cell. 2011 Apr 1;145(1):17-8
[PMID:
21458663
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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