Document Detail


Presynaptic dopamine modulation by stimulant self-administration.
MedLine Citation:
PMID:  23277050     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mesolimbic dopamine system is an essential participant in the initiation and modulation of various forms of goal-directed behavior, including drug reinforcement and addiction processes. Dopamine neurotransmission is increased by acute administration of all drugs of abuse, including the stimulants cocaine and amphetamine. Chronic exposure to these drugs via voluntary self-administration provides a model of stimulant abuse that is useful in evaluating potential behavioral and neurochemical adaptations that occur during addiction. This review describes commonly used methodologies to measure dopamine and baseline parameters of presynaptic dopamine regulation, including exocytotic release and reuptake through the dopamine transporter in the nucleus accumbens core, as well as dramatic adaptations in dopamine neurotransmission and drug sensitivity that occur with acute non-contingent and chronic, contingent self-administration of cocaine and amphetamine.
Authors:
Rodrigo A Espana; Sara R Jones
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-09-09     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Central Nervous System Stimulants / administration & dosage*
Dopamine / metabolism*
Dopamine Plasma Membrane Transport Proteins / metabolism
Humans
Limbic System / drug effects,  metabolism
Presynaptic Terminals / drug effects*,  metabolism*
Self Administration
Street Drugs
Synaptic Transmission / drug effects
Grant Support
ID/Acronym/Agency:
K01 DA025279/DA/NIDA NIH HHS; P50 DA006634/DA/NIDA NIH HHS; P50 DA06634/DA/NIDA NIH HHS; R01 DA021325/DA/NIDA NIH HHS; R01 DA021325/DA/NIDA NIH HHS; R01 DA030161/DA/NIDA NIH HHS; R01 DA030161/DA/NIDA NIH HHS; R21 DA018815/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; 0/Dopamine Plasma Membrane Transport Proteins; 0/Street Drugs; VTD58H1Z2X/Dopamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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