Document Detail

Presymptomatic neuropsychological impairment in Huntington's disease.
MedLine Citation:
PMID:  2968784     Owner:  NLM     Status:  MEDLINE    
Ten asymptomatic individuals at risk for Huntington's disease (HD) were determined by the use of linked DNA probes to have a high (HD+ group) or low (HD- group) probability of having inherited the mutant gene. Neuropsychological examination, performed without knowledge of DNA results, revealed impairments in five of seven subjects in the HD+ group. Abnormalities were related to visuospatial abilities or to functions associated with the frontal lobes. All three subjects in the HD- group showed no neuropsychological impairment. Statistical analyses confirmed differences between the HD+ and HD- groups. Affected parents of subjects were at least 12 years older at symptom onset. These results demonstrate that clear neuropsychological impairment may be present in HD even when overt signs and symptoms are not expected for a number of years.
G W Jason; E M Pajurkova; O Suchowersky; J Hewitt; C Hilbert; J Reed; M R Hayden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  45     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-05     Completed Date:  1988-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  769-73     Citation Subset:  AIM; IM    
Department of Clinical Neurosciences, University of Calgary, Alberta, Canada.
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MeSH Terms
Huntington Disease / complications*,  genetics,  physiopathology
Intelligence Tests
Mental Disorders / complications*,  psychology
Nervous System Diseases / complications*,  physiopathology
Neuropsychological Tests

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