Document Detail


Presumptive fenbendazole toxicosis in North American porcupines.
MedLine Citation:
PMID:  16618230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CASE DESCRIPTION: 4 North American porcupines were evaluated because of diarrhea or neutropenia (or both) that developed after treatment with fenbendazole for intestinal parasites. CLINICAL FINDINGS: Complete blood cell count abnormalities included severe neutropenia in all affected porcupines and mild anemia in some of them. In 2 porcupines, postmortem findings included bone marrow hypoplasia and intestinal crypt cell necrosis. TREATMENT AND OUTCOME: Affected porcupines received supportive care including fluid supplementation and broad-spectrum antimicrobials. The 2 surviving animals recovered after 9 to 33 days of treatment. CONCLUSIONS AND CLINICAL RELEVANCE: Fenbendazole is an anthelminthic that may be used in an extralabel manner for the treatment of intestinal parasitism in wildlife species. The drug inhibits mitosis and can affect rapidly dividing cell lines, such as those in the bone marrow and intestinal crypt mucosa. Fenbendazole may not be an appropriate anthelminthic choice in North American porcupines.
Authors:
Martha A Weber; Michele A Miller; Donald L Neiffer; Scott P Terrell
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  228     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2006-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1240-2     Citation Subset:  IM    
Affiliation:
Disney's Animal Kingdom, PO Box 10000, Lake Buena Vista, FL 32830, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antinematodal Agents / adverse effects*,  therapeutic use
Blood Cell Count / veterinary
Diarrhea / chemically induced,  veterinary
Fatal Outcome
Female
Fenbendazole / adverse effects*,  therapeutic use
Intestinal Diseases, Parasitic / drug therapy,  veterinary
Male
Porcupines*
Chemical
Reg. No./Substance:
0/Antinematodal Agents; 43210-67-9/Fenbendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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