| Pressure--volume relationships of tracheae in fetal newborn and adult rabbits. | |
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MedLine Citation:
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PMID: 7280379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The physical properties of the trachea in fetal, newborn, and adult rabbits change with age. Tracheal dimensions and pressure--volume relationships were determined in excised tracheae at a wide developmental age range (from early gestational age to infancy and adulthood). At intraluminal pressures of 0 to 10 cm H2O, the tracheal specific compliance was 0.089 (cm H2O)(-1) for a 21 day old fetus. By adulthood, the tracheal specific compliance decreased five fold to 0.017 (cm H2O)(-1); a dramatic proportion of this reduction occurred during fetal life itself, followed by a steady, progressive decline to adult age. The volume of the tracheal segment, at intraluminal pressure of 20 cm H2O, increased by 29% (adult), 41.5% (31 day fetus) and 113% (21 day fetus). Developmental alterations in the specific airway compliance suggest significant changes in anatomical dead space would occur as a function of maturation and airway transmural pressure. |
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Authors:
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V K Bhutani; S D Rubenstein; T H Shaffer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Respiration physiology Volume: 43 ISSN: 0034-5687 ISO Abbreviation: Respir Physiol Publication Date: 1981 Mar |
Date Detail:
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Created Date: 1981-11-24 Completed Date: 1981-11-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047142 Medline TA: Respir Physiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 221-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Animals, Newborn / physiology* Rabbits Respiratory Physiological Phenomena* Trachea / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL22843/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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