Document Detail


Pressure--volume relationships of tracheae in fetal newborn and adult rabbits.
MedLine Citation:
PMID:  7280379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physical properties of the trachea in fetal, newborn, and adult rabbits change with age. Tracheal dimensions and pressure--volume relationships were determined in excised tracheae at a wide developmental age range (from early gestational age to infancy and adulthood). At intraluminal pressures of 0 to 10 cm H2O, the tracheal specific compliance was 0.089 (cm H2O)(-1) for a 21 day old fetus. By adulthood, the tracheal specific compliance decreased five fold to 0.017 (cm H2O)(-1); a dramatic proportion of this reduction occurred during fetal life itself, followed by a steady, progressive decline to adult age. The volume of the tracheal segment, at intraluminal pressure of 20 cm H2O, increased by 29% (adult), 41.5% (31 day fetus) and 113% (21 day fetus). Developmental alterations in the specific airway compliance suggest significant changes in anatomical dead space would occur as a function of maturation and airway transmural pressure.
Authors:
V K Bhutani; S D Rubenstein; T H Shaffer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  43     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-11-24     Completed Date:  1981-11-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  221-31     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Animals, Newborn / physiology*
Rabbits
Respiratory Physiological Phenomena*
Trachea / physiology*
Grant Support
ID/Acronym/Agency:
HL22843/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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