Document Detail

Pressure-volume loops: feasible for the evaluation of right ventricular function in an experimental model of acute pulmonary regurgitation?
MedLine Citation:
PMID:  19470501     Owner:  NLM     Status:  MEDLINE    
Pressure-volume loop measurements by cardiac catheterization constitute a highly reliable method for the direct beat-to-beat functional analysis of the heart. We aimed to prove its feasibility for the instantaneous evaluation of right ventricular performance in a novel experimental model of pulmonary regurgitation (PR). Four-month-old sheep (n=18, weighing 35-45 kg) were operated via left anterior thoracotomy. A transannular patch (TAP) was sutured to the right ventricular outflow tract (RVOT). Pulmonary valve annulus was transsected through an incision over the patch without the need for cardiopulmonary bypass. Baseline right ventricular function was obtained by inserting conductance catheters through the pulmonary artery before and immediately after surgical induction of PR. All animals survived. Pressure-volume loop analysis presented immediate significant elevations in pressure and volume loading of the right ventricle. Maximum developed pressure incremented from 26.9+/-1.1 mmHg to 30.5+/-0.9 mmHg (P<0.01). End-diastolic volume [62.4+/-3.4-102.7+/-8.6 ml (P<0.01)] increased as well. Peak rate of pressure rise increased during ejection phase, and heart rate rose from 427.1+/-21.4 mmHg/s to 492.6+/-24.7 mmHg/s (P<0.01) and from 89.0+/-3.0/min to 93.0+/-3.3/min (P=0.04), respectively. Right ventricular ejection fraction decreased from 74.1+/-2.7% to 56.6+/-3.0% (P<0.01). Our results demonstrate that the conductance catheter method is feasible for the evaluation of acute right ventricular volume overload in this new model of PR with TAP augmentation of RVOT.
Can Yerebakan; Christian Klopsch; Stephanie Prietz; Johannes Boltze; Brigitte Vollmar; Andreas Liebold; Gustav Steinhoff; Eugen Sandica
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-05-26
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  9     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Department of Cardiac Surgery, Medical Faculty, University of Rostock, Schillingallee 35, 18057 Rostock, Germany.
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MeSH Terms
Cardiac Surgical Procedures
Disease Models, Animal
Feasibility Studies
Heart Catheterization*
Heart Rate
Predictive Value of Tests
Pulmonary Valve Insufficiency / diagnosis*,  physiopathology
Stroke Volume*
Ventricular Function, Right*
Ventricular Pressure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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