Document Detail

Pressure-volume curves of the respiratory system.
MedLine Citation:
PMID:  15636647     Owner:  NLM     Status:  MEDLINE    
The quasi-static pressure-volume (P-V) curve of the respiratory system describes the mechanical behavior of the lungs and chest wall during inflation and deflation. To eliminate resistive and convective acceleration effects, the measurement of volume and pressure must be performed during short periods of apnea or during very slow flow. There are 3 main techniques for acquiring quasi-static P-V curves: the supersyringe method, the constant flow method, and the multiple-occlusion (or ventilator) method. For the information to be interpreted correctly, one must understand the interaction between the lungs and the chest wall, the effects of the supine position, and the meaning of hysteresis. The P-V curve has been studied in many disease states, but it has been applied most extensively to patients with acute respiratory distress syndrome, in hopes that it might allow clinicians to customize ventilator settings according to a patient's individual respiratory mechanics and thus protect the patient from ventilator-induced lung injury. However, lack of standardization of the procedure used to acquire P-V curves, difficulties in measuring absolute lung volume, lack of knowledge regarding how to use the information, and a paucity of data showing a benefit in morbidity and mortality with the use of P-V curves have tempered early enthusiasm regarding the clinical usefulness of the quasi-static P-V curve.
R Scott Harris
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Respiratory care     Volume:  50     ISSN:  0020-1324     ISO Abbreviation:  Respir Care     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-07     Completed Date:  2005-04-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-98; discussion 98-9     Citation Subset:  IM    
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
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MeSH Terms
Emphysema / physiopathology
Heart Failure / physiopathology
Lung / physiology*
Lung Compliance / physiology
Lung Diseases / physiopathology*
Obesity / complications
Posture / physiology
Respiratory Mechanics*
Thoracic Wall / physiology
Total Lung Capacity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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