Document Detail

Pressure variation during ventilator generated nasal intermittent positive pressure ventilation in preterm infants.
MedLine Citation:
PMID:  20488862     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nasal intermittent positive pressure ventilation (NIPPV) is a mode of non-invasive respiratory support. Its mechanisms of action and optimal delivery techniques are unknown. AIM: This observational study aimed to investigate and quantify delivered peak pressures during non-synchronised ventilator-generated NIPPV. METHODS: Infants born below 30 weeks gestation receiving ventilator-generated NIPPV delivered via Hudson prongs were recruited. Intraprong pressure, change in tidal volume, respiratory rate, oxygen saturations, inspired oxygen and video images were recorded. RESULTS: Eleven infants (four infants were female) of median (interquartile range; IQR) gestational age 25(+/-3) (25(+/-2) 26(+/-0)) weeks and birth weight 732 (699-895) g, were studied at 24 (19-41) days of age. Six infants, with set peak pressure (peak inflation pressure; PIP) of 20 cm H(2)O, received a median pressure of 15.9 (IQR 13.6-17.9) cm H(2)O. 37% of inflations were delivered at least 5 cm H(2)O below set PIP. 12.7% of inflations were delivered above set PIP. Five infants with set PIP of 25 cm H(2)O received a median PIP of 17.2 (IQR 15.0-18.3) cm H(2)O. 83% of inflations were delivered at least 5 cm H(2)O below set PIP, with 6.1% delivered higher than set PIP. The difference in delivered PIP between the groups was 1.3 cm H(2)O. PIP was highest and most variable when the infant was moving. Delivered PIP did not vary whether it coincided with spontaneous inspiration or expiration. CONCLUSION: During ventilator-generated non-synchronised NIPPV delivered PIP was variable and frequently lower than set PIP. Delivered PIP was occasionally greater than set PIP.
L S Owen; C J Morley; P G Davis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-20
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  95     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-18     Completed Date:  2010-10-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F359-64     Citation Subset:  AIM; IM    
Royal Women's Hospital, Locked Bag 300, Parkville VIC 3052, Australia.
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MeSH Terms
Air Pressure
Birth Weight
Gestational Age
Infant, Newborn
Infant, Premature / physiology*
Intermittent Positive-Pressure Ventilation / methods*
Oxygen Consumption / physiology
Plethysmography / methods
Respiratory Rate / physiology
Tidal Volume / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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