Document Detail

Pressure tracings in obstructive Tako-Tsubo cardiomyopathy.
MedLine Citation:
PMID:  17027331     Owner:  NLM     Status:  MEDLINE    
A 70-year-old female experienced severe anxiety due to an incident with a stranger when she was home alone at night. Immediately after the event, she had an oppressive chest sensation; 16 h later she was admitted to hospital. Left ventriculography showed akinesia of the mid-to-distal portion and hyperkinesia of the basal portion of the left ventricular chamber. However, coronary angiography showed no significant coronary artery disease. We diagnosed her as having Tako-Tsubo cardiomyopathy. Subsequently, left ventricular and central aortic pressures were recorded simultaneously. Initial recording showed a peak systolic gradient of 60 mm Hg. On the first sinus beat after a premature ventricular contraction, the peak systolic gradient increased to 130 mm Hg, and the pulse pressure decreased. Shortly after intravenous administration of nitroglycerin (0.5 mg), central aortic pressure decreased and the peak systolic gradient increased to 100 mm Hg. On the first sinus beat after a premature ventricular contraction, the peak systolic gradient increased to 160 mm Hg, and the pulse pressure decreased. Five minutes after intravenous nitroglycerin, the peak systolic gradient returned to 70 mm Hg. Follow-up transthoracic echocardiography 13 days later showed normal left ventricular wall motion with no pressure gradient through the left ventricular outflow tract.
Satoshi Kurisu; Ichiro Inoue; Takuji Kawagoe; Masaharu Ishihara; Yuji Shimatani; Yasuharu Nakama; Eisuke Kagawa
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-10-05
Journal Detail:
Title:  European journal of heart failure     Volume:  9     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-06-19     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  317-9     Citation Subset:  IM    
Department of Cardiology, Hiroshima City Hospital 7-33, Moto-machi, Naka-ku, Hiroshima 730-8518, Japan. <>
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MeSH Terms
Blood Pressure*
Cardiomyopathies / diagnosis*,  drug therapy,  physiopathology
Echocardiography / methods
Myocardial Contraction / physiology
Nitroglycerin / therapeutic use
Vasodilator Agents / therapeutic use
Ventricular Outflow Obstruction / diagnosis*,  drug therapy,  physiopathology
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin
Comment In:
Eur J Heart Fail. 2007 Aug;9(8):854; author reply 855   [PMID:  17652022 ]

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