Document Detail

Pressure reversal of the effect of urethane on the evoked somatosensory cortical response in the rat.
MedLine Citation:
PMID:  7426834     Owner:  NLM     Status:  MEDLINE    
1 The cerebral response evoked by stimulation of the forepaw in the rat shows an increase in latency and decrease in the amplitude of its initial components as anaesthetic dose (urethane) is increased. 2 These changes are reversed if the ambient pressure is increased with helium and the electrocorticogram shows an increase in basic frequency. 3 The dose of urethane needed to prevent reflex response to tail stimulation is increased as pressure increases. 4. The implications of these behavioural and somatosensory responsiveness changes as pressure is increased are discussed.
A Angel; D A Gratton; M J Halsey; B Wardley-Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  70     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  241-7     Citation Subset:  IM    
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MeSH Terms
Atmospheric Pressure*
Behavior, Animal / drug effects
Electric Stimulation
Evoked Potentials / drug effects
Somatosensory Cortex / drug effects*,  physiology*
Urethane / pharmacology*
Reg. No./Substance:

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