Document Detail


Pressure response in the yeast Saccharomyces cerevisiae: from cellular to molecular approaches.
MedLine Citation:
PMID:  15529754     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Yeasts are unicellular organisms that are exposed to a highly variable environment, concerning the availability of nutrients, temperature, pH, radiation, access to oxygen and, specially, water activity. Evolution has selected yeasts to tolerate, to a certain extent, these environmental stresses. High hydrostatic pressure (HHP) exerts a broad effect upon yeast cells, interfering with the cell membranes, cellular architecture and in processes ofpolymerisation and denaturation of proteins. Gene expression patterns in response to HHP revealed a stress response profile. The majority of the upregulated genes were involved in stress defence and carbohydrate metabolism while most of the repressed ones were in cell cycle progression and protein synthesis categories. In addition, in the present work it was seen that mild pressure induced cell cycle arrest and protection against severe stresses, such as high temperature, high pressure and ultra cold shock. Nevertheless, this protection was only significant if the cells were incubated at atmospheric pressure after the HHP treatment. Expression of genes that were upregulated by HHP and are related to resistance to this stresses were also analyzed, and, for the majority of them, higher induction was attained after 15 min post-pressurization. Taken together, the results imply an interconnection among stresses.
Authors:
F L Palhano; H L Gomes; M T D Orlando; E Kurtenbach; P M B Fernandes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cellular and molecular biology (Noisy-le-Grand, France)     Volume:  50     ISSN:  0145-5680     ISO Abbreviation:  Cell. Mol. Biol. (Noisy-le-grand)     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-11-08     Completed Date:  2005-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9216789     Medline TA:  Cell Mol Biol (Noisy-le-grand)     Country:  France    
Other Details:
Languages:  eng     Pagination:  447-57     Citation Subset:  IM    
Affiliation:
Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Av. Marechal Campos, Vitória, ES, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / genetics
Cell Cycle / genetics
Equipment Design
Gene Expression Profiling
Hydrostatic Pressure*
Saccharomyces cerevisiae / cytology,  genetics,  physiology*
Signal Transduction
Temperature

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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