Document Detail

Pressure oscillations after flow interruption in relation to lung mechanics.
MedLine Citation:
PMID:  8904014     Owner:  NLM     Status:  MEDLINE    
The value of interrupter resistance measurements has been questioned because these depend on equilibration between alveolar (PA) and mouth pressure (PAO), which may not occur during airway obstruction or in measurements in children. In order to determine whether airway geometry and its interaction with the lung volume can be obtained without complete pressure equilibration, the postocclusional oscillatory airway opening pressure transients PAO(t) after flow interruption were studied in comparison to airway resistance (RAW), lung volumes (TGV, VC) and MEF50 in 9 healthy children (7-14 y) and 5 adults (28-37 y) in both time and frequency domains. The frequency of pressure oscillations was correlated to TGV (p < 0.01). Its damping properties (d) were correlated to MEF50 (p < 0.005). Performing airflow interruptions in the same subject showed that d increased at low lung volumes. During bronchial challenge test, d significantly increased with carbachol and decreased with salbutamol, whereas the frequency decreased with carbachol and increased with salbutamol. Therefore, the analysis of postocclusional pressure oscillations can be used to assess relative changes in airway mechanics and its interaction with lung volume during bronchial challenge tests in patients such as children with poor cooperation.
U Frey; A Schibler; R Kraemer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  102     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-03-14     Completed Date:  1997-03-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  225-37     Citation Subset:  IM    
Pulmonary Function Lab., Department of Paediatrics, University of Berne, Switzerland.
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MeSH Terms
Airway Obstruction
Airway Resistance
Albuterol / pharmacology
Carbachol / pharmacology
Lung / physiology*
Lung Volume Measurements
Respiratory Mechanics / physiology*
Reg. No./Substance:
18559-94-9/Albuterol; 51-83-2/Carbachol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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