| Pressure-induced gastric accommodation studied with a new distension paradigm. Abnormally low accommodation rate in patients with functional dyspepsia. | |
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MedLine Citation:
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PMID: 16638696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: A new distension paradigm, by which the gastric volume response to ramp-tonic distension can be analysed in detail, has been developed. The aim of this study was to investigate the applicability of this new paradigm in man, and to compare pressure-induced gastric accommodation in healthy volunteers (HV) and patients with functional dyspepsia (FD). MATERIAL AND METHODS: Ten HV, and 11 FD patients were examined twice; once in the fasting state and once postprandially. Intragastric bag pressure was raised from 1 to 12 mmHg in 4 min (ramp phase) and then kept constant for 5 min (tonic phase). RESULTS: Compared to HV, fasting FD patients had lower gastric accommodation rates (0.9+/-0.2 versus 2.5+/-0.4 ml/s, p=0.002), lower maximum volume (239+/-39 versus 428+/-64 ml, p=0.01) and a longer accommodation time (157+/-26 versus 92+/-15 s, p=0.03). A test meal prior to distension tended to normalize the response in FD patients. CONCLUSIONS: This new barostat paradigm allowed detailed analysis of short-term pressure-induced accommodation in man. Impaired gastric distension-induced accommodation is a novel abnormality in FD. |
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Authors:
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Johan A Lunding; Solomon Tefera; Alfred Bayati; Odd Helge Gilja; Hillevi Mattsson; Trygve Hausken; Arnold Berstad |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 41 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-26 Completed Date: 2006-10-05 Revised Date: 2007-03-21 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
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Languages: eng Pagination: 544-52 Citation Subset: IM |
Affiliation:
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Section for Gastroenterology, Haukeland University Hospital, Institute of Medicine and National Centre of Ultrasound in Gastroenterology, Bergen, Norway. johan.lunding@med.uib.no |
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| MeSH Terms | |
Descriptor/Qualifier:
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Artifacts Dyspepsia / physiopathology* Fasting Gastroscopy Humans Postprandial Period Pressure Reference Values Stomach / anatomy & histology, physiology*, physiopathology |
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