Document Detail

Pressure-induced apoptosis in human lymphoblasts.
MedLine Citation:
PMID:  9281364     Owner:  NLM     Status:  MEDLINE    
The viability of human lymphoblasts was investigated after compression at 37 degrees C for 30 min. Immediately after decompression, necrotic cells were observed and the viability decreased sigmoidally to 0 with increasing pressure from 85 to 200 MPa. Apoptotic cells began to be observed from 8 h after decompression in the case of compression at 100 MPa for 30 min at 37 degrees C. The apoptosis was confirmed to be pressure-induced by the Tunel method and by optical and electron microscopy. Cell death by both necrosis and apoptosis due to compression was accelerated in the S phase of the cell cycle.
K J Takano; T Takano; Y Yamanouchi; T Satou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental cell research     Volume:  235     ISSN:  0014-4827     ISO Abbreviation:  Exp. Cell Res.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-30     Completed Date:  1997-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  IM    
Institute of Materials Science, University of Tsukuba, Tsukuba, Japan.
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MeSH Terms
Cell Survival
Cells, Cultured
Chromatin / ultrastructure
DNA / biosynthesis
DNA Fragmentation
Lymphocytes / cytology*,  physiology*,  ultrastructure
Microscopy, Electron
Nuclear Envelope / ultrastructure
Time Factors
Reg. No./Substance:
0/Chromatin; 9007-49-2/DNA

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