| Pressure-derived measurement of coronary flow reserve. | |
| | |
MedLine Citation:
|
PMID: 15653018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: We aimed to validate the technique of measuring the coronary flow reserve (CFR) with coronary pressure measurements against an established thermodilution technique. BACKGROUND: The CFR has traditionally required measurement of coronary blood flow velocity with the Doppler wire and, more recently, using a thermodilution technique with the coronary pressure wire. However, recent work has suggested that the CFR may be derived from pressure measurements alone (the ratio of the square root of the pressure drop across an epicardial stenosis during hyperemia to that value at rest). This depends on the assumption that friction losses across a coronary stenosis are negligible. METHODS: We compared pressure-derived CFR values with those obtained by the thermodilution technique using the intracoronary pressure wire in 38 stenoses in 34 patients with significant coronary stenoses undergoing percutaneous intervention. We also compared these two techniques of measuring CFR in 25 stenoses (6 vessels) artificially created by inflating small balloons within a stented coronary artery after percutaneous intervention. RESULTS: There is a close linear relationship between pressure-derived and thermodilution CFR in native (r(2) = 0.52; p < 0.001) and artificial stenoses (r(2) = 0.54; p < 0.05), although the pressure-derived technique appears to systematically underestimate CFR values in both situations. This applies to native and artificial stenoses. CONCLUSIONS: Coronary flow reserve cannot be measured merely with pressure alone, and it cannot be safely assumed that friction losses are negligible across a native coronary stenosis. These data suggest that friction loss is an important determinant of the pressure gradient along an atherosclerotic coronary artery. |
| | |
Authors:
|
Philip MacCarthy; Alexandre Berger; Ganesh Manoharan; Jozef Bartunek; Emanuele Barbato; William Wijns; Guy R Heyndrickx; Nico H J Pijls; Bernard De Bruyne |
Related Documents
:
|
2632688 - Correlations between st-segment depressions in patients with arterial hypertension and ... 1152498 - Effects of systemic-pulmonary shunts on regional myocardial blood flow in experimental ... 3155428 - Systemic and coronary hemodynamics of labetalol in normotensive patients with ischemic ... 10752548 - Interaction between transient metabolically mediated dilatation and pressure induced co... 1102838 - Asthma mortality: an analysis of one years experience, review of the literature and ass... 17421018 - Feasibility and clinical impact of transcatheter closure of interatrial communications ... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 45 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2005 Jan |
Date Detail:
|
Created Date: 2005-01-17 Completed Date: 2005-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 216-20 Citation Subset: AIM; IM |
Affiliation:
|
Cardiovascular Center, OLV Clinic, Aalst, Belgium. philip@maccarthy.co.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Algorithms Blood Flow Velocity / physiology* Blood Pressure / physiology* Cardiac Volume* Coronary Circulation / physiology* Coronary Stenosis / physiopathology* Female Heart Catheterization Humans Hyperemia / physiopathology Male Middle Aged Severity of Illness Index Thermodilution* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of embolic particles with the Doppler guide wire during coronary intervention in patients ...
Next Document: Health-related quality of life after interventional or conservative strategy in patients with unstab...