| Pressure-derived fractional flow reserve to assess serial epicardial stenoses: theoretical basis and animal validation. | |
| | |
MedLine Citation:
|
PMID: 10769286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Background-Fractional flow reserve (FFR) is an index of stenosis severity validated for isolated stenoses. This study develops the theoretical basis and experimentally validates equations for predicting FFR of sequential stenoses separately. Methods and Results-For 2 stenoses in series, equations were derived to predict FFR (FFR(pred)) of each stenosis separately (ie, as if the other one were removed) from arterial pressure (P(a)), pressure between the 2 stenoses (P(m)), distal coronary pressure (P(d)), and coronary occlusive pressure (P(w)). In 5 dogs with 2 stenoses of varying severity in the left circumflex coronary artery, FFR(pred) was compared with FFR(app) (ratio of the pressure just distal to that just proximal to each stenoses) and to FFR(true) (ratio of the pressures distal to proximal to each stenosis but after removal of the other one) in case of fixed distal and varying proximal stenoses (n=15) and in case of fixed proximal and varying distal stenoses (n=20). The overestimation of FFR(true) by FFR(app) was larger than that of FFR(true) by FFR(pred) (0.070+/-0.007 versus 0.029+/-0.004, P<0.01 for fixed distal stenoses, and 0.114+/-0.01 versus 0.036+/-0. 004, P<0.01 for fixed proximal stenoses). This overestimation of FFR(true) by FFR(app) was larger for fixed proximal than for fixed distal stenoses. Conclusions-The interaction between 2 stenoses is such that FFR of each lesion separately cannot be calculated by the equation for isolated stenoses (P(d)/P(a) during hyperemia) applied to each separately but can be predicted by more complete equations taking into account P(a), P(m), P(d), and P(w). |
| | |
Authors:
|
B De Bruyne; N H Pijls; G R Heyndrickx; D Hodeige; R Kirkeeide; K L Gould |
Related Documents
:
|
21544086 - G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to di... 1994756 - Influence of desflurane on regional distribution of coronary blood flow in a chronicall... 3184926 - Surface-induced hypothermia: effects on coronary blood flow autoregulation and vascular... 8039846 - Coronary artery constriction caused by the cold pressor test in human hypertension. 9243256 - Effect of efonidipine, a novel dihydropyridine derivative, on myocardial metabolic chan... 2916426 - Regional and global biventricular function during dipyridamole stress testing. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Circulation Volume: 101 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2000 Apr |
Date Detail:
|
Created Date: 2000-05-04 Completed Date: 2000-05-04 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1840-7 Citation Subset: AIM; IM |
Affiliation:
|
Cardiovascular Center, Aalst, Belgium. bernard.de.bruyne@olvz-aalst.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Collateral Circulation / physiology Coronary Circulation* Coronary Disease / diagnosis* Dogs Hemodynamics / physiology Models, Cardiovascular |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart.
Next Document: Stimulation of bradykinin B(1) receptors induces vasodilation in conductance and resistance coronary...