Document Detail


Pressure-assisted cell spinning: a direct protocol for spinning biologically viable cell-bearing fibres and scaffolds.
MedLine Citation:
PMID:  18458477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We recently pioneered the ability to directly electrospin living cells from which scaffolds to membranes were derived. This protocol, now widely referred to as 'cell electrospinning', is currently undergoing in-depth investigations where the post-treated cell's global gene expression to its sub-cellular components is being investigated for understanding any effects post-treating. Our motivation is to develop this method for the biomedical sciences, in particular for applications in regenerative and therapeutic medicine. In the current work, we unveil a direct cell spinning protocol which is non-electric field driven and which will compete directly with cell electrospinning. We referred to this processing method as 'pressure-assisted spinning' in our previous studies, where we demonstrated this route as an emerging micro/nanotechnology. In the current context, we refer to this processing protocol as 'pressure-assisted cell spinning' (PACS). Our developmental studies on PACS reported here show, for the first time, that this technique could be explored as an alternative approach to cell electrospinning. Pressure-assisted cell spinning now enters the direct biological scaffold to membrane formation league.
Authors:
Sumathy Arumuganathar; Scott Irvine; Jean R McEwan; Suwan N Jayasinghe
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Publication Detail:
Type:  Journal Article     Date:  2007-09-24
Journal Detail:
Title:  Biomedical materials (Bristol, England)     Volume:  2     ISSN:  1748-605X     ISO Abbreviation:  -     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-05-06     Completed Date:  2008-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101285195     Medline TA:  Biomed Mater     Country:  England    
Other Details:
Languages:  eng     Pagination:  211-9     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Fractionation / instrumentation*,  methods
Cell Separation / instrumentation*,  methods
Cells, Cultured
Equipment Design
Equipment Failure Analysis
Micromanipulation / instrumentation*,  methods
Muscle, Smooth, Vascular / cytology*,  physiology*
Rabbits
Rotation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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