Document Detail

Pressure-assisted cell spinning: a direct protocol for spinning biologically viable cell-bearing fibres and scaffolds.
MedLine Citation:
PMID:  18458477     Owner:  NLM     Status:  MEDLINE    
We recently pioneered the ability to directly electrospin living cells from which scaffolds to membranes were derived. This protocol, now widely referred to as 'cell electrospinning', is currently undergoing in-depth investigations where the post-treated cell's global gene expression to its sub-cellular components is being investigated for understanding any effects post-treating. Our motivation is to develop this method for the biomedical sciences, in particular for applications in regenerative and therapeutic medicine. In the current work, we unveil a direct cell spinning protocol which is non-electric field driven and which will compete directly with cell electrospinning. We referred to this processing method as 'pressure-assisted spinning' in our previous studies, where we demonstrated this route as an emerging micro/nanotechnology. In the current context, we refer to this processing protocol as 'pressure-assisted cell spinning' (PACS). Our developmental studies on PACS reported here show, for the first time, that this technique could be explored as an alternative approach to cell electrospinning. Pressure-assisted cell spinning now enters the direct biological scaffold to membrane formation league.
Sumathy Arumuganathar; Scott Irvine; Jean R McEwan; Suwan N Jayasinghe
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Publication Detail:
Type:  Journal Article     Date:  2007-09-24
Journal Detail:
Title:  Biomedical materials (Bristol, England)     Volume:  2     ISSN:  1748-605X     ISO Abbreviation:  -     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-05-06     Completed Date:  2008-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101285195     Medline TA:  Biomed Mater     Country:  England    
Other Details:
Languages:  eng     Pagination:  211-9     Citation Subset:  IM    
Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
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MeSH Terms
Cell Fractionation / instrumentation*,  methods
Cell Separation / instrumentation*,  methods
Cells, Cultured
Equipment Design
Equipment Failure Analysis
Micromanipulation / instrumentation*,  methods
Muscle, Smooth, Vascular / cytology*,  physiology*

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