| Pressure-volume relationship during dobutamine stress echocardiography predicts exercise tolerance in patients with congestive heart failure. | |
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MedLine Citation:
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PMID: 19962273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The pressure-volume relationship (PVR) is a useful method for evaluating left ventricular (LV) myocardial contractility during dobutamine stress echocardiography (DSE). The investigators assessed PVRs, systolic and diastolic function, B-type natriuretic peptide (BNP) levels, and aerobic exercise capacity in patients with congestive heart failure (CHF). METHODS: A total of 84 patients with CHF (mean age, 68 +/- 9 years) underwent high-dose DSE. PVR was defined as the systolic cuff pressure/end-systolic volume index difference between rest and peak DSE. Of these, 67 patients also underwent cardiopulmonary exercise testing. The patients were divided into 3 equal groups on the basis of PVR: lower, intermediate, and higher. RESULTS: PVRs were significantly lower in more symptomatic patients (New York Heart Association class II vs III) (2.17 +/- 1.99 vs 0.91 +/- 0.72 mm Hg/mL/m(2), P < .001). Patients with elevated LV filling pressures (E/Ea >or= 14) showed significantly lower PVRs compared with patients with normal or slightly abnormal LV filling pressures (1.1 +/- 1.1 vs 2.96 +/- 3.11 mm Hg/mL/m(2), P = .006). Patients with higher PVRs showed lower logarithmically transformed BNP levels (2.0 +/- 0.5, 2.5 +/- 0.3, and 2.6 +/- 0.5 pg/mL; P < .001), higher peak oxygen consumption (17 +/- 4, 13 +/- 3, and 12 +/- 3 mL/kg/min; P < .001), and higher rest-stress percentage changes in ejection fraction (80 +/- 50%, 56 +/- 29%, and 22 +/- 32%; P < .001) compared with patients with intermediate and lower PVRs, respectively. The parameters predictive of exercise tolerance were PVR (odds ratio [OR]; 1.582, 95% confidence interval [CI], 1.136-2.204; P = .007), ejection fraction (OR, 1.172; 95% CI, 1.070-1.283; P = .001), log BNP (OR, 0.080; 95% CI, 0.020-0.325; P < .001), and E/Ea (OR, 0.836; 95% CI, 0.733-0.953; P = .007). CONCLUSIONS: In patients with CHF, impaired noninvasively assessed myocardial contractility is related to impaired systolic and diastolic function, higher BNP levels, and poorer exercise tolerance. |
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Authors:
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Quirino Ciampi; Lorenza Pratali; Tonino Bombardini; Michele Della Porta; Bruno Petruzziello; Bruno Villari; Eugenio Picano; Rosa Sicari |
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Publication Detail:
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Type: Journal Article Date: 2009-12-03 |
Journal Detail:
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Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 23 ISSN: 1097-6795 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-05-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: United States |
Other Details:
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Languages: eng Pagination: 71-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Fatebenefratelli Hospital, Benevento, Italy. qciampi@iol.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure Dobutamine / diagnostic use* Echocardiography / methods* Exercise Test Exercise Tolerance* Female Heart Failure / physiopathology*, ultrasonography* Humans Male Natriuretic Peptide, Brain / blood* Stroke Volume Vasodilator Agents / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 114471-18-0/Natriuretic Peptide, Brain; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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