Document Detail

Pressor sensitivity to angiotensin I and angiotensin II during the development of experimental renal hypertension in the rat.
MedLine Citation:
PMID:  3024889     Owner:  NLM     Status:  MEDLINE    
Treatment with the potent angiotensin converting enzyme inhibitor perindopril completely prevented any rise in blood pressure in the 2-kidney, 1-clip (2K1C) model of renal hypertension in rats. Withdrawal of this inhibitor was followed by a slow rise in blood pressure. In 2K1C rats treated with perindopril, pressor responses to angiotensin I fell during the treatment period, but returned to normal after the inhibitor was stopped. Pressor responses to angiotensin II (AII) increased during treatment with perindopril; this was presumably due to increased receptor sensitivity consequent on the falls in endogenous AII levels. Responses to AII fell to control levels after the inhibitor was stopped. It is concluded that an increased pressor sensitivity to AII is not the cause of the slowly developing hypertension in the 2K1C model of hypertension, and that the slow pressor response to AII must be due to other factors.
A E Doyle; S B Harrap; J Torresi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  13     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1987-01-28     Completed Date:  1987-01-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  563-8     Citation Subset:  IM    
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MeSH Terms
Angiotensin I / pharmacology*
Angiotensin II / pharmacology*
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Hypertension, Renal / drug therapy,  physiopathology*
Indoles / pharmacology
Oligopeptides / physiology
Pressoreceptors / drug effects*,  physiology
Rats, Inbred Strains
Reg. No./Substance:
0/Indoles; 0/Oligopeptides; 11128-99-7/Angiotensin II; 35115-60-7/Teprotide; 82834-16-0/Perindopril; 9041-90-1/Angiotensin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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