Document Detail

Pressor-induced responses of the cat ventral medullary surface.
MedLine Citation:
PMID:  7864225     Owner:  NLM     Status:  MEDLINE    
We examined ventral medullary surface activity using light reflectance procedures after blood pressure alterations induced by phenylephrine or sodium nitroprusside in 23 pentobarbital sodium-anesthetized cats. Images of reflected 660-nm light were collected and digitized at 1- to 3-s intervals after baseline and intravenous saline, 5-40 micrograms/kg phenylephrine, or sodium nitroprusside infusion. Carotid sinus nerve denervation (CSD) and bilateral vagotomy were performed in five and three animals, respectively, and challenges were repeated. Phenylephrine elicited a dose-dependent transient blood pressure elevation and reflectance increase (interpreted as activity decline) over the entire ventral medullary surface examined. The increase consisted of an initial rapid transient component, peaking at 45 s, and a 3- to 5-min recovery. CSD enhanced, and vagotomy substantially reduced, the initial transient response to phenylephrine. Sodium nitroprusside-induced lowering of blood pressure was associated with decreased reflectance in rostral sites and increased reflectance in caudal regions. CSD abolished a late component and diminished amplitude of an initial rapidly rising component of changes induced by nitroprusside, a decline further accentuated by addition of vagotomy.
R M Harper; D Gozal; G Aljadeff; J L Carroll; X W Dong; D M Rector
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  268     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-20     Completed Date:  1995-03-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R324-33     Citation Subset:  IM    
Department of Anatomy and Cell Biology, University of California Los Angeles School of Medicine 90024.
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MeSH Terms
Blood Pressure / drug effects,  physiology*
Carotid Sinus / innervation
Cerebral Cortex / drug effects
Medulla Oblongata / drug effects,  physiology*
Nitroprusside / pharmacology
Optics and Photonics
Phenylephrine / pharmacology
Grant Support
Reg. No./Substance:
15078-28-1/Nitroprusside; 59-42-7/Phenylephrine

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