Document Detail

Pressor and hormonal responses to intravenous injection of metoclopramide in normotensive and hypertensive patients.
MedLine Citation:
PMID:  2232366     Owner:  NLM     Status:  MEDLINE    
To assess the dopaminergic regulation of blood pressure and the renin-angiotensin-aldosterone system in fourteen essential hypertension (EHT) and six normotensives (NT), intravenous injections of 10 mg of the dopamine antagonist, metoclopramide (MCP), were given. Essential hypertension patients were divided into two subgroups according to the basal values of plasma renin activity (PRA). Plasma prolactin (PRL), aldosterone (ALDO), norepinephrine (NE) and epinephrine (E) in seven high-renin EHT revealed significantly higher basal values than normal- and low-renin EHT. Intravenous injections of MCP caused significant increases in PRL and ALDO but not in NE, E and PRA in all subjects. However, in high-renin EHT the responses of PRL and ALDO were significantly marked compared to other subjects. In spite of these hormonal changes after MCP, blood pressure was unaltered. The present data suggest that "tonic inhibition" of PRL and ALDO by the dopaminergic system is partially regulated by the renin-angiotensin system regardless of the levels of blood pressure.
H Kawabe; H Suzuki; Y Itaya; T Saruta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of medicine     Volume:  29     ISSN:  0021-5120     ISO Abbreviation:  Jpn. J. Med.     Publication Date:    1990 Mar-Apr
Date Detail:
Created Date:  1990-12-20     Completed Date:  1990-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247713     Medline TA:  Jpn J Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  174-9     Citation Subset:  IM    
Department of Internal Medicine, School of Medicine, Keio University, Japan.
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MeSH Terms
Aldosterone / blood
Blood Pressure / drug effects*,  physiology
Dopamine / physiology
Hypertension / drug therapy,  physiopathology
Injections, Intravenous
Metoclopramide / administration & dosage,  pharmacology*
Prolactin / blood
Renin / blood
Renin-Angiotensin System / drug effects*,  physiology
Reg. No./Substance:
364-62-5/Metoclopramide; 52-39-1/Aldosterone; 9002-62-4/Prolactin; EC

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