| Pressor and hormonal responses to intravenous injection of metoclopramide in normotensive and hypertensive patients. | |
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MedLine Citation:
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PMID: 2232366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the dopaminergic regulation of blood pressure and the renin-angiotensin-aldosterone system in fourteen essential hypertension (EHT) and six normotensives (NT), intravenous injections of 10 mg of the dopamine antagonist, metoclopramide (MCP), were given. Essential hypertension patients were divided into two subgroups according to the basal values of plasma renin activity (PRA). Plasma prolactin (PRL), aldosterone (ALDO), norepinephrine (NE) and epinephrine (E) in seven high-renin EHT revealed significantly higher basal values than normal- and low-renin EHT. Intravenous injections of MCP caused significant increases in PRL and ALDO but not in NE, E and PRA in all subjects. However, in high-renin EHT the responses of PRL and ALDO were significantly marked compared to other subjects. In spite of these hormonal changes after MCP, blood pressure was unaltered. The present data suggest that "tonic inhibition" of PRL and ALDO by the dopaminergic system is partially regulated by the renin-angiotensin system regardless of the levels of blood pressure. |
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Authors:
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H Kawabe; H Suzuki; Y Itaya; T Saruta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese journal of medicine Volume: 29 ISSN: 0021-5120 ISO Abbreviation: Jpn. J. Med. Publication Date: 1990 Mar-Apr |
Date Detail:
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Created Date: 1990-12-20 Completed Date: 1990-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0247713 Medline TA: Jpn J Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 174-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, School of Medicine, Keio University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood Blood Pressure / drug effects*, physiology Dopamine / physiology Humans Hypertension / drug therapy, physiopathology Injections, Intravenous Male Metoclopramide / administration & dosage, pharmacology* Prolactin / blood Renin / blood Renin-Angiotensin System / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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364-62-5/Metoclopramide; 52-39-1/Aldosterone; 9002-62-4/Prolactin; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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