Document Detail

Pressor effects following microinjection of 5-HT1A receptor agonists into the raphe obscurus of the anaesthetized rat.
MedLine Citation:
PMID:  1673069     Owner:  NLM     Status:  MEDLINE    
1. The effects of electrical stimulation and microinjections (90 nl) of the 5-HT1A receptor agonists, flesinoxan and 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), and glutamate into the raphe obscurus on blood pressure, heart rate and phrenic nerve activity (central inspiratory drive) were investigated in rats anaesthetized with alpha-chloralose. 2. Electrical stimulation of the raphe obscurus caused a rise in blood pressure which was associated with bradycardia, while glutamate (2.7 nmol) caused only a rise in blood pressure. 3. Flesinoxan (1.3 nmol) and 8-OH-DPAT (0.7 nmol) increased blood pressure by 9 +/- 1 and 14 +/- 2 mmHg, respectively and did not affect heart rate. For both agonists the effect on blood pressure was shown to be dose-dependent; again no effect on the heart rate was observed over the dose-ranges chosen. 4. Microinjections of the non-selective 5-HT1A receptor antagonists, (+/-)-pindolol (2.7 nmol) or methiothepin (5.2 nmol), into the raphe obscurus prevented the increase in blood pressure caused by microinjection of flesinoxan. However, (+/-)-pindolol caused a sustained rise in blood pressure of 15 +/- 1 mmHg while methiothepin caused a transient rise in blood pressure. Neither drugs affected heart rate. The ability of methiothepin to attenuate the pressor effect of flesinoxan was found to be partially reversed after 30 min. 5. It is suggested that activation of 5-HT1A receptors within the raphe obscurus can cause sympatho-excitation.
G H Dreteler; W Wouters; P R Saxena; A G Ramage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  102     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-23     Completed Date:  1991-05-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  317-22     Citation Subset:  IM    
Academic Department of Pharmacology, Royal Free Hospital School of Medicine, Hampstead, London.
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MeSH Terms
Blood Pressure / drug effects*,  physiology
Electric Stimulation
Glutamates / administration & dosage
Glutamic Acid
Heart Rate / drug effects,  physiology
Methiothepin / administration & dosage
Phrenic Nerve / drug effects,  physiology
Pindolol / administration & dosage
Piperazines / administration & dosage
Raphe Nuclei / drug effects*,  physiology
Rats, Inbred Strains
Receptors, Serotonin / classification,  drug effects*,  physiology
Tetrahydronaphthalenes / administration & dosage
Reg. No./Substance:
0/Glutamates; 0/Piperazines; 0/Receptors, Serotonin; 0/Tetrahydronaphthalenes; 13523-86-9/Pindolol; 20229-30-5/Methiothepin; 56-86-0/Glutamic Acid; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin; 98206-10-1/flesinoxan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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