Document Detail


Pressor doses of vasopressin result in only transient elevations in plasma peptide levels.
MedLine Citation:
PMID:  22227112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We recently reported that neuronostatin, a novel neuropeptide, biphasically increased mean arterial pressure, first through the activation of the sympathetic nervous system followed by the release of vasopressin. In those experiments, we found that centrally administered neuronostatin increased plasma vasopressin levels only 2-3 times greater than levels observed in saline-treated controls, and that the increase in mean arterial pressure (approximately 15 mm Hg) could be blocked by pretreatment with a V1-vasopressin antagonist. Here we report the relationship between two to three fold elevations in plasma vasopressin levels and concomitant changes in mean arterial pressure in conscious, unrestrained male rats. We injected increasing doses of vasopressin (5, 20, and 100 ng/kg, intra-arterially) and measured both changes in plasma vasopressin levels and the elevation in mean arterial pressure achieved. At 5-min post injection, plasma levels of vasopressin and mean arterial pressures were similar to those observed following central neuronostatin administration in our earlier study. Thus we conclude that small increases in circulating vasopressin levels can result in significant elevations in mean arterial pressure at least in the conscious rat.
Authors:
Gina L C Yosten; Willis K Samson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-12-31
Journal Detail:
Title:  Peptides     Volume:  33     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-28     Completed Date:  2012-06-19     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  342-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104, United States. gyosten@slu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Half-Life
Male
Rats
Rats, Sprague-Dawley
Vasoconstrictor Agents / pharmacokinetics*,  pharmacology
Vasopressins / pharmacokinetics*,  pharmacology
Grant Support
ID/Acronym/Agency:
R01 HL066023-06/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 11000-17-2/Vasopressins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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