Document Detail


Pressor action of angiotensin I at the ventrolateral medulla: effect of selective angiotensin blockade.
MedLine Citation:
PMID:  8856170     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study we explored the possibility that angiotensin-(1-7) (Ang-(1-7)) is involved in the control of blood pressure at the rostral ventrolateral medulla (RVLM) by determining the effect of angiotensin antagonists (DuP 753 and A-779) and the effect of the angiotensin converting enzyme inhibitor, ramiprilat on the pressor action produced by angiotensin I (Ang I). The pressor effect produced by bilateral microinjection of Ang I into the RVLM of anesthetized rats was not significantly altered by DuP 753 or by the ACE inhibitor ramiprilat. Conversely, the Ang-(1-7) antagonist, A-779, reduced significantly the pressor effect produced by Ang I. These data suggest that in our experimental condition Ang I was preferentially converted to Ang-(1-7) at RVLM, or that Ang I and/or one of its fragments acts through a receptor blocked by A-779.
Authors:
D X Lima; M A Fontes; R C Oliveira; M J Campagnole-Santos; M C Khosla; R A Santos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunopharmacology     Volume:  33     ISSN:  0162-3109     ISO Abbreviation:  Immunopharmacology     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1997-02-10     Completed Date:  1997-02-10     Revised Date:  2012-07-03    
Medline Journal Info:
Nlm Unique ID:  7902474     Medline TA:  Immunopharmacology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  305-7     Citation Subset:  IM    
Affiliation:
Departamento de Fisiologia and Biofísica, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin I / administration & dosage,  pharmacology*,  physiology
Angiotensin II / analogs & derivatives,  pharmacology,  physiology
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Animals
Biphenyl Compounds / pharmacology
Blood Pressure / drug effects*,  physiology
Imidazoles / pharmacology
Losartan
Male
Medulla Oblongata / drug effects*,  physiology*
Microinjections
Peptide Fragments / pharmacology,  physiology
Ramipril / analogs & derivatives,  pharmacology
Rats
Rats, Wistar
Receptors, Angiotensin / physiology
Tetrazoles / pharmacology
Chemical
Reg. No./Substance:
0/7-Ala-angiotensin (1-7); 0/Angiotensin Receptor Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Biphenyl Compounds; 0/Imidazoles; 0/Peptide Fragments; 0/Receptors, Angiotensin; 0/Tetrazoles; 0/angiotensin I (1-7); 11128-99-7/Angiotensin II; 114798-26-4/Losartan; 87269-97-4/ramiprilat; 87333-19-5/Ramipril; 9041-90-1/Angiotensin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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