Document Detail

Preserved metabolic reserve capacity in skeletal muscle of post-infarction heart failure patients.
MedLine Citation:
PMID:  20874858     Owner:  NLM     Status:  In-Data-Review    
It has been proposed that exercise capacity during whole body exercise in post-infarction congestive heart failure (CHF) patients is limited by skeletal muscle function. We therefore investigated the balance between cardiopulmonary and muscular metabolic capacity. CHF patients (n=8) and healthy subjects (HS, n=12) were included. Patients with coronary artery disease (CAD, n=8) were included as a control for medication. All subjects performed a stepwise incremental load test during bicycling (∼24 kg muscle mass), two-legged knee extensor (2-KE) exercise (∼4 kg muscle mass) and one-legged knee extensor (1-KE) exercise (∼2 kg muscle mass). Peak power and peak pulmonary oxygen uptake (VO(2peak) ) increased and muscle-specific VO(2peak) decreased with an increasing muscle mass involved in the exercise. Peak power and VO(2peak) were lower for CHF patients than HS, with values for CAD patients falling between CHF patients and HS. During bicycling, all groups utilized 24-29% of the muscle-specific VO(2peak) as measured during 1-KE exercise, with no difference between the groups. Hence, the muscle metabolic reserve capacity during whole body exercise is not different between CHF patients and HS, indicating that appropriately medicated and stable post-infarction CHF patients are not more limited by intrinsic skeletal muscle properties during whole body exercise than HS.
G Slettaløkken; T A Rehn; M Munkvik; B Rud; M Sökjer-Petersen; P K Lunde; I Sjaastad; O M Sejersted; J Hallén
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Publication Detail:
Type:  Journal Article     Date:  2010-09-28
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  22     ISSN:  1600-0838     ISO Abbreviation:  Scand J Med Sci Sports     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  199-206     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Norwegian School of Sport Sciences (NSSS), Oslo, NorwayInstitute for Experimental Medical Research, Oslo University Hospital (OUH), Ullevål, NorwayCenter for Heart Failure Research, University of Oslo (UIO), Oslo, NorwayDepartment of Cardiovascular Radiology, Oslo University Hospital (OUH), Oslo, NorwayDepartment of Cardiology, Oslo University Hospital (OUH), Oslo, Norway.
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