| Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure. | |
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MedLine Citation:
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PMID: 18385117 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To examine myocardial deformation and rotation in patients with heart failure, and elucidate the underlying mechanisms that account for normal ejection fraction (EF) in patients with diastolic heart failure (DHF). METHODS AND RESULTS: Fifty consecutive patients presenting with congestive heart failure (age: 58 +/- 16 years) underwent simultaneous right heart catheterization and transthoracic echocardiography. Left ventricular (LV) volumes, mass, EF, meridional, and circumferential wall stress were measured in addition to haemodynamic measurements. 2-D speckle tracking was applied to measure longitudinal, radial, and circumferential strain and twist. Twist was reduced only in patients with systolic heart failure (SHF: 5 +/- 2 degrees, DHF: 13 +/- 6 degrees, control: 14 +/- 5 degrees, P < 0.001). Circumferential strain was not different between DHF (-15 +/- 5%) and control groups (-20 +/- 3%, P > 0.05), though it was significantly lower in patients with SHF (-7 +/- 3%, P < 0.05). Importantly, longitudinal (DHF:-12%, SHF: -4%, control: -19%, P < 0.001) and radial (DHF: 28 +/- 9%, SHF: 14 +/- 8%, control: 47 +/- 7%, P < 0.001) strains were significantly lower in both heart failure groups than in controls, and were depressed to a larger extent in SHF patients than in those with DHF (both P < 0.05). CONCLUSION: LV longitudinal and radial strains are reduced, but circumferential deformation and twist are normal in DHF patients. On the other hand, in patients with SHF, longitudinal, radial, and circumferential deformation, and twist are all reduced. Multivariable regression analysis suggests that preserved LV twist and circumferential strain may contribute to normal EF in patients with DHF. |
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Authors:
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Jianwen Wang; Dirar S Khoury; Yong Yue; Guillermo Torre-Amione; Sherif F Nagueh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-02 |
Journal Detail:
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Title: European heart journal Volume: 29 ISSN: 1522-9645 ISO Abbreviation: Eur. Heart J. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-15 Completed Date: 2008-07-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 1283-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Methodist DeBakey Heart Center, The Methodist Hospital, Houston, TX 77030-2717, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Heart Failure, Diastolic / physiopathology* Humans Male Middle Aged Sex Characteristics Stress, Mechanical Stroke Volume / physiology Ventricular Function |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2008 May;29(10):1215-7
[PMID:
18434423
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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