Document Detail

Preserved heart rate variability identifies low-risk patients with nonischemic dilated cardiomyopathy: results from the DEFINITE trial.
MedLine Citation:
PMID:  16500299     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The recent expansion of indications for prophylactic implantable cardioverter-defibrillator (ICD) placement in subjects with nonischemic dilated cardiomyopathy has raised concerns about the cost-effectiveness of this therapy. OBJECTIVES: The purpose of this study was to identify low-risk patients with nonischemic dilated cardiomyopathy who may not require prophylactic ICD placement. METHODS: This was a prospective study of 274 participants in the Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) trial, a randomized controlled trial that evaluated the role of prophylactic ICD placement in patients with nonischemic dilated cardiomyopathy. The patients underwent 24-hour Holter recording for analysis of heart rate variability (HRV). The primary HRV variable was the standard deviation of normal R-R intervals (SDNN). Patients with atrial fibrillation and frequent ventricular ectopy (>25% of beats) were excluded from HRV analysis (23% of patients). SDNN was categorized in tertiles, and Kaplan-Meier analysis was performed to compare survival in the three tertiles and excluded patients. RESULTS: The study population was 73% male, with a mean age of 59 +/- 12 years and mean left ventricular ejection fraction of 21% +/- 6%. After 3-year follow-up, significant differences in mortality rates were observed: SDNN >113 ms: 0 (0%), SDNN 81-113 ms: 5 (7%), SDNN <81 ms: 7 (10%), excluded patients: 11 (17%) (P = .03). There were no deaths in the tertile with SDNN >113 ms regardless of treatment assignment (ICD vs control). CONCLUSION: Patients with nonischemic dilated cardiomyopathy and preserved HRV have an excellent prognosis and may not benefit from prophylactic ICD placement. Patients with severely depressed HRV and patients who are excluded from HRV analysis because of atrial fibrillation and frequent ventricular ectopy have the highest mortality.
Eric J Rashba; N A Mark Estes; Paul Wang; Andi Schaechter; Adam Howard; Wojciech Zareba; Jean-Philippe Couderc; Juha Perkiomaki; Joseph Levine; Alan Kadish
Related Documents :
19850699 - Characteristics and clinical significance of late gadolinium enhancement by contrast-en...
9386169 - Evaluation of the spatial aspects of t-wave complexity in the long-qt syndrome.
8296739 - Frequency and significance of conduction defects early after orthotopic heart transplan...
20233789 - Number of electrocardiogram leads displaying the diagnostic coved-type pattern in bruga...
7431589 - The baseline ecg in the evaluation of acute cardiac complaints.
21535189 - Seemingly healthy skin in atopic dermatitis: observations with the use of high-frequenc...
19942259 - Fibrin clot properties in acute ischemic stroke: relation to neurological deficit.
7192809 - Neurologic prognosis after cardiopulmonary arrest: iii. seizure activity.
15513009 - Topical phenylephrine may result in worsening of visual loss when used to dilate pupils...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Heart rhythm : the official journal of the Heart Rhythm Society     Volume:  3     ISSN:  1547-5271     ISO Abbreviation:  Heart Rhythm     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-27     Completed Date:  2006-10-13     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  101200317     Medline TA:  Heart Rhythm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  281-6     Citation Subset:  IM    
Division of Cardiology, Department of Medicine, University of Maryland at Baltimore, 22 South Greene Street, Room N3W77, Baltimore, MD 21201, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiomyopathy, Dilated / mortality,  physiopathology*,  therapy
Cost-Benefit Analysis
Death, Sudden, Cardiac / prevention & control
Defibrillators, Implantable / economics,  utilization*
Electrocardiography, Ambulatory
Follow-Up Studies
Heart Rate*
Middle Aged
Prospective Studies
Risk Factors
Stroke Volume
Survival Analysis
Grant Support
Comment In:
Heart Rhythm. 2006 Mar;3(3):287-9   [PMID:  16500300 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Efficacy of catheter ablation of atrial fibrillation in patients with hypertrophic obstructive cardi...
Next Document:  Diurnal variation of ventricular repolarization in a large family with LQT3-Brugada syndrome charact...