Document Detail


Preserved flow-mediated dilation in the inactive legs of spinal cord-injured individuals.
MedLine Citation:
PMID:  14988075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to assess endothelial function, measured by flow-mediated dilation (FMD), in an inactive extremity (leg) and chronically active extremity (arm) within one subject. Eleven male spinal cord-injured (SCI) individuals and eleven male controls (C) were included. Echo Doppler measurements were performed to measure FMD responses after 10 and 5 min of arterial occlusion of the leg (superficial femoral artery, SFA) and the arm (brachial artery, BA), respectively. A nitroglycerine spray was administered to determine the endothelium independent vasodilatation in the SFA. In the SFA, relative changes in FMD were significantly enhanced in SCI compared with C (SCI: 14.1 +/- 1.3%; C: 9.2 +/- 2.3%), whereas no differences were found in the BA (SCI: 12.5 +/- 2.9%; C: 14.2 +/- 3.3%). Because the FMD response is directly proportional to the magnitude of the stimulus, the FMD response was also expressed relative to the shear rate. No differences between the groups were found for the FMD-to-shear rate ratio in the SFA (SCI:0.061 +/- 0.023%/s(-1); C: 0.049 +/- 0.024%/s(-1)), whereas the FMD-to-shear rate ratio was significantly decreased in the BA of SCI individuals (SCI: 0.037 +/- 0.01%/s(-1); C: 0.061 +/- 0.027%/s(-1)). The relative dilatory response to nitroglycerine did not differ between the groups. (SCI: 15.6 +/- 2.0%; C: 13.4 +/- 2.3%). In conclusion, our results indicate that SCI individuals have a preserved endothelial function in the inactive legs and possibly an attenuated endothelial function in the active arms compared with controls.
Authors:
Patricia C E de Groot; Fleur Poelkens; Miriam Kooijman; Maria T E Hopman
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Publication Detail:
Type:  Journal Article     Date:  2004-02-26
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  287     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-22     Completed Date:  2004-07-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H374-80     Citation Subset:  IM    
Affiliation:
Department of Physiology, University Medical Centre, Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Adult
Arm / blood supply,  physiopathology
Blood Vessels / ultrasonography
Brachial Artery / physiopathology
Case-Control Studies
Endothelium, Vascular / physiopathology
Femoral Artery / physiopathology
Humans
Hyperemia / physiopathology
Leg / blood supply*,  physiopathology*
Male
Nitroglycerin / administration & dosage
Regional Blood Flow
Spinal Cord Injuries / physiopathology*
Stress, Mechanical
Ultrasonography, Doppler
Vasodilation*
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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