Document Detail

Preserved endothelial integrity and nitric oxide synthase in saphenous vein grafts harvested by a 'no-touch' technique.
MedLine Citation:
PMID:  11531869     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The saphenous vein is the most commonly used conduit for coronary artery bypass surgery, but 1-year occlusion rates as high as 30 per cent have been reported. In conventional surgery, considerable damage to the vein occurs during harvesting. The aim of this study was to compare endothelial integrity and nitric oxide synthase (NOS) in saphenous veins harvested by a novel 'no-touch' technique and veins harvested conventionally. METHODS: Immunohistochemistry was used to study endothelial integrity, and a combination of histochemistry and autoradiography was employed to identify NOS in human saphenous veins harvested by conventional and no-touch techniques. RESULTS: The endothelial lining of conventional grafts was reduced compared with that of no-touch grafts (52 versus 73 per cent; P = 0.04). This was associated with a concomitant reduction of NOS availability; NOS was also present in the adventitial vasa vasorum of no-touch vessels. CONCLUSION: Some of the sites with potential for nitric oxide release in vivo are removed during conventional saphenous vein harvesting. These sites were preserved after no-touch harvesting, suggesting the potential to improve coronary artery bypass graft patency.
J C Tsui; D S Souza; D Filbey; V Bomfim; M R Dashwood
Related Documents :
25399659 - The importance of microscopic examination of the lungs in decedents with sustained cent...
8997279 - Nitric oxide-dependent opposite effects of somatostatin on arterial and venous caliber ...
1081799 - Aneurysms of an aorto-coronary artery saphenous vein bypass graft--a case report.
9768999 - Facilitated vascular anastomoses: the one-shot device.
9485279 - Modified minimally invasive technique for greater saphenous vein harvesting.
3573769 - Valvulotomy in in situ vein bypasses performed by angioscope-assisted laser probe.
15019669 - S100 protein and its relation to cerebral microemboli in on-pump and off-pump coronary ...
24138519 - Novel approaches for prevention of stroke related to transcatheter aortic valve implant...
9756429 - Homocysteine associated hypercoagulability and disseminated thrombosis--a case report.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  88     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  1209-15     Citation Subset:  AIM; IM    
Department of Surgery, Royal Free and University College Medical School, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Collagen / metabolism
Coronary Artery Bypass / methods
Endothelium, Vascular / enzymology*,  pathology
Middle Aged
NADPH Dehydrogenase / metabolism
Nitric Oxide Synthase / metabolism*
Saphenous Vein / enzymology,  pathology,  transplantation*
Specimen Handling / adverse effects
Reg. No./Substance:
9007-34-5/Collagen; EC Oxide Synthase; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Preservation of endothelial integrity and function in experimental vascular anastomosis with non-pen...
Next Document:  Quality of life after low anterior resection with total mesorectal excision and temporary loop ileos...