Document Detail

Preserved cardiac performance with reduced left ventricular mass in conscious exercising spontaneously hypertensive rats.
MedLine Citation:
PMID:  7930559     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate whether cardiovascular performance can be modified beneficially with left ventricular hypertrophy reversal and whether the associated sudden afterload increases may adversely affect overall cardiac performance. METHODS: We studied cardiovascular performance with thermodilution techniques at rest and during maximal treadmill exercise after 3 weeks' treatment with the angiotensin converting enzyme inhibitor quinapril (3 mg/kg per day) in 19 male spontaneously hypertensive rats (SHR) aged 20 weeks. RESULTS: Left ventricular mass was reduced significantly, without impairment of exercise performance, demonstrating that left ventricular hypertrophy reversal benefited or at least did not hinder cardiovascular adaptation to physiologic exercise in the SHR. Moreover, decreasing the afterload did not further improve the performance after the reversal of left ventricular hypertrophy.
F Soria; E D Frohlich; D Aristizabal; K Kaneko; M Kardon; J Hunter; B Pegram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  12     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-11-22     Completed Date:  1994-11-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  585-9     Citation Subset:  IM    
Alton Ochsner Medical Foundation, New Orleans, LA 70121.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Heart / drug effects,  physiopathology*
Hypertension / pathology,  physiopathology*
Hypertrophy, Left Ventricular / drug therapy*,  pathology,  physiopathology*
Isoquinolines / therapeutic use
Myocardium / pathology
Physical Exertion*
Rats, Inbred SHR
Reg. No./Substance:
0/Antihypertensive Agents; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 82586-55-8/quinapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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