| Preserved cardiac beta-adrenergic sensitivity in early renovascular hypertension. | |
| | |
MedLine Citation:
|
PMID: 3032789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To determine the mechanism of blunted sympathetic reflex responses in early renovascular hypertension, we measured inotropic and chronotropic responses of the heart to beta-adrenergic stimulation in vivo and myocardial beta-adrenergic receptor number and adenylate cyclase activity in 10 dogs during an early stage of one-kidney renal hypertension. Mean aortic pressure was higher in the hypertensive dogs (152 +/- 4 mm Hg) than in eight sham-operated dogs (122 +/- 1 mm Hg; p less than 0.001), but heart rate, cardiac output, and left atrial pressure did not differ between the two groups. Blood pressure reduction with a direct-acting vasodilator, pinacidil, resulted in marked increases in heart rate (+97 +/- 12 beats/min) and rate of change of left ventricular pressure (dP/dt; +1447 +/- 367 mm Hg/sec) in normotensive dogs but only blunted heart rate (+54 +/- 12 beats/min) and minimal left ventricular dP/dt (+376 +/- 264 mm Hg/sec) responses in hypertensive dogs. In contrast, intravenously administered isoproterenol produced similar increases in heart rate and left ventricular dP/dt in the two groups. These two groups also did not differ in either left ventricular beta-adrenergic receptor number and affinity or basal, isoproterenol-stimulated, and fluoride-stimulated adenylate cyclase activity. Thus, despite blunted reflex responses to blood pressure reduction, hypertensive dogs showed neither reduction in chronotropic and inotropic responses to direct beta-adrenergic stimulation nor beta-adrenergic desensitization of the myocardium, as assessed by beta-adrenergic receptor number and adenylate cyclase activity. Blunted reflex responses in this model of early hypertension must be due to factors operating at some locus other than the beta-adrenergic receptor-adenylate cyclase complex. |
| | |
Authors:
|
W R Davidson; S Kawashima; S P Banerjee; C S Liang |
Related Documents
:
|
2693499 - Dilevalol: a selective beta-2 adrenergic agonist vasodilator with beta adrenergic block... 22890219 - Distribution of mean, systolic and diastolic ocular perfusion pressure in telemedical h... 15726879 - Propranolol increases the complexity of heart rate fluctuations--a mode of antiarrhythm... 22299669 - Isoproterenol stress test during catheterization of patients with coarctation of the ao... 2867049 - Current status of labetalol, the first alpha- and beta-blocking agent. 3967499 - Hemodynamic effects of verapamil in the beta-blocked dog. 16240049 - Pressure dependence for the co quantum yield in the photolysis of acetone at 248 nm: a ... 11408259 - Relationship between ultrasonically detected phasic antral contractions and antral pres... 8577209 - Staurosporine inhibits the effects of leukotrienes c4 and d4 in isolated guinea pig hea... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Hypertension Volume: 9 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1987 May |
Date Detail:
|
Created Date: 1987-06-05 Completed Date: 1987-06-05 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 467-72 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenylate Cyclase
/
metabolism Animals Blood Pressure / drug effects* Dogs Guanidines / pharmacology* Heart Rate / drug effects Heart Ventricles / metabolism Hemodynamics / drug effects Hypertension, Renovascular / physiopathology* Isoproterenol / pharmacology* Kinetics Male Myocardium / metabolism Norepinephrine / metabolism Pinacidil Receptors, Adrenergic, beta / drug effects* Vasodilator Agents / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
AG-03234/AG/NIA NIH HHS; HL-07220/HL/NHLBI NIH HHS; HL-30194/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Guanidines; 0/Receptors, Adrenergic, beta; 0/Vasodilator Agents; 51-41-2/Norepinephrine; 7683-59-2/Isoproterenol; 85371-64-8/Pinacidil; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Red blood cell Na+,K+-ATPase in men with newly diagnosed or previously treated essential hypertensio...
Next Document: Cytochemically assayable Na+,K+-ATPase inhibition by Milan hypertensive rat plasma.