Document Detail

Preservation of ovarian function by ovarian transposition prior to concurrent chemotherapy and pelvic radiation for cervical cancer. A case report and review of the literature.
MedLine Citation:
PMID:  20527239     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: For over 45 years, ovarian transposition has been proposed for patients with cervical cancer to preserve ovarian function prior to pelvic radiation. We report a case of preservation of ovarian function and regular normal menstrual cycles after pelvic cisplatin-based chemoradiation and perform a literature review. CASE: A 29-year-old female with cervical cancer underwent laparoscopic ovarian transposition prior to cisplatin-based chemoradiation. At 3-year follow-up after completion of her chemoradiation treatment indicated that she was still free of any disease. She is experiencing normal menstrual cycles at regular monthly intervals. CONCLUSION: The present case shows that it is possible to retain ovarian function and menstrual cycles by ovarian transposition prior to pelvic chemoradiation. This provides an option for cervical cancer patients who desire preservation of ovarian function.
M C W M Bloemers; L Portelance; C Legler; M C Renaud; S L Tan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  31     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-08     Completed Date:  2010-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  194-7     Citation Subset:  IM    
Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
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MeSH Terms
Adenocarcinoma / drug therapy*,  radiotherapy*
Antineoplastic Agents / therapeutic use
Cisplatin / therapeutic use
Combined Modality Therapy
Fertility / physiology
Gynecologic Surgical Procedures / methods*
Ovary / transplantation*
Radiation-Sensitizing Agents / therapeutic use
Transplantation, Autologous / methods*
Treatment Outcome
Uterine Cervical Neoplasms / drug therapy*,  radiotherapy*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Radiation-Sensitizing Agents; 15663-27-1/Cisplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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