Document Detail

Preservation of myocardial energy-rich phosphates by retrograde application of Bretschneider cardioplegia during aortocoronary bypass surgery.
MedLine Citation:
PMID:  3078419     Owner:  NLM     Status:  MEDLINE    
The efficacy of myocardial protection obtained by antegrade application of a cardioplegic solution was compared with that obtained by retrograde application via the coronary sinus. Myocardial preservation was assessed using biochemical parameters, i.e. tissue content of lactate, creatine phosphate, nucleotides, nucleosides and hypoxanthine. Nineteen patients undergoing routine aortocoronary bypass surgery were randomly allocated to a study group. During cardiac arrest induced by antegrade Bretschneider cardioplegia, myocardial tissue content of creatine phosphate dropped to 52% of its pre-ischemic value and degradation of nucleotides occurred, characterized mainly by an accumulation of adenosine. Retrograde cardioplegia prevented this catabolism of energy-rich phosphates completely during ischemic cardiac arrest and is therefore considered to be superior to antegrade cardioplegia.
P J Walter; W Flameng; R Kindl; T Podzuweit
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  2     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  1988  
Date Detail:
Created Date:  1990-04-11     Completed Date:  1990-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
Department of Cardiovascular Surgery, University Hospital Antwerp, Belgium.
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MeSH Terms
Adenosine / metabolism
Adenosine Monophosphate / metabolism
Cardioplegic Solutions / administration & dosage*
Coronary Artery Bypass / methods*
Lactates / metabolism
Myocardium / metabolism*
Phosphates / metabolism*
Phosphocreatine / metabolism
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Cardioplegic Solutions; 0/Lactates; 0/Phosphates; 58-61-7/Adenosine; 61-19-8/Adenosine Monophosphate; 67-07-2/Phosphocreatine

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