Document Detail


Preservation of high-energy phosphate reserves in a cat model of post-ischemic myocardial dysfunction.
MedLine Citation:
PMID:  1601606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brief episodes of myocardial ischemia are known to cause reversible depression of regional myocardial contraction after reperfusion. One of the mechanisms of this persistent regional dysfunction has been proposed to be depletion of high-energy phosphate compounds. Eight cats were prepared with a reversible snare occluder around the left anterior descending artery (LAD); a surface coil sutured to the epicardial surface over the LAD territory for measurement of 31-phosphorus (31P) magnetic resonance spectroscopy (MRS) spectra; and a pair of ultrasonic crystals implanted in the mid-myocardium for measurement of regional segment length shortening. The baseline value of percent segment length shortening (%SS) was 12.8 +/- 1.4%. Increased afterload did not significantly alter high-energy phosphate levels or %SS. All animals exhibited passive systolic bulging during occlusion (-8.4 +/- 3.6% systolic shortening) as well as reduced phosphocreatine (PRc, 30 +/- 3% of control) and increased inorganic phosphorus (Pi) (239 +/- 18%), but there was no change in adenosine triphosphate (ATP). During reflow, %SS did not completely recover (4.0 +/- 2.9%, P less than .05 versus baseline). PCr and Pi returned to control levels during the first 30 minutes of reperfusion. Increased afterload had no significant effect on high-energy phosphates or %SS in stunned hearts. These findings indicate a lack of correlation between recovery of high-energy phosphate stores and regional myocardial contractility in stunned myocardium. High-energy phosphate reserves are preserved in stunned myocardium and are unlikely to be a direct cause of myocardial dysfunction.
Authors:
M Saeed; M F Wendland; S Wagner; N Derugin; C B Higgins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative radiology     Volume:  27     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-07-16     Completed Date:  1992-07-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-52     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of California, San Francisco 94143.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Cats
Coronary Disease / etiology,  physiopathology*
Disease Models, Animal*
Electrocardiography
Energy Metabolism / physiology*
Magnetic Resonance Spectroscopy
Myocardial Contraction / physiology
Myocardial Reperfusion Injury / etiology,  physiopathology*
Myocardium / metabolism
Phosphates / metabolism*
Time Factors
Grant Support
ID/Acronym/Agency:
8LRO1HL 32283-06/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Phosphates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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