| Preservation of autoregulation of cerebral blood flow in autonomic failure. | |
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MedLine Citation:
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PMID: 7354367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral blood flow (CBF) measurements have been made at systolic pressures between 40 and 170 mm Hg in 8 patients with chronic autonomic failure and widespread sympathetic efferent defects. Hypotension was produced by head up tilt. Cerebral autoregulation was preserved over a wide range and only failed at a systolic pressure close to 60 mm Hg, which is below the level at which it fails in normal subjects. Therefore, although autoregulation is probably mediated largely by local myogenic factors, its lower limit appears to be reduced by defective sympathetic function. These findings help to explain the remarkable tolerance of severe postural hypotension in autonomic failure. |
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Authors:
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D J Thomas; R Bannister |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 44 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1980 Jan |
Date Detail:
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Created Date: 1980-04-23 Completed Date: 1980-04-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 205-12 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrophy Autonomic Nervous System* Blood Pressure Cerebrovascular Circulation* Female Homeostasis Humans Hypotension, Orthostatic / physiopathology Male Middle Aged Nervous System Diseases / physiopathology* Sympathetic Nervous System Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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