Document Detail


Preservation of Myocardium During Coronary Artery Bypass Surgery.
MedLine Citation:
PMID:  22528557     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Myocardial protection aims to prevent reversible post-ischemic cardiac dysfunction (myocardial stunning) and irreversible myocardial cell death (myocardial infarction) that occur as a consequence of myocardial ischemia and/or ischemic-reperfusion injury. Although the mortality rate for isolated coronary artery bypass grafting has been markedly reduced during the past decade, myocardial death, as evidenced by elevation in creatine kinase-myocardial band and/or cardiac troponin, is common. This is ascribed to suboptimal myocardial protection during cardiopulmonary bypass or with off-pump technique, early graft failure, distal embolization, and regional or global myocardial ischemia during surgery. An unmet need in contemporary coronary bypass surgery is to find more effective cardioprotective strategies that have the potential for decreasing the morbidity and mortality associated with suboptimal cardioprotection. In the present review article on myocardial protection in contemporary coronary artery bypass surgery, we attempt to elucidate the clinical problems, summarize the outcomes of selected phase III trials, and introduce new perspectives.
Authors:
Takeshi Kinoshita; Tohru Asai
Related Documents :
18996047 - Alterations in circulating activin a, gdf-15, tgf-beta3 and mmp-2, -3, and -9 during on...
7777727 - Coarctation of the aorta.
17620687 - Percutaneous treatment of catheter-induced dissection of the right coronary artery and ...
12809397 - Delayed presentation of injury to the sinus of valsalva with aortic regurgitation resul...
1563877 - Identification of recurrent ischemia after coronary artery bypass surgery: a comparison...
23737577 - An unusual aetiology for internuclear ophthalmoplegia.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Current cardiology reports     Volume:  -     ISSN:  1534-3170     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Cardiovascular Surgery, Shiga University of Medical Science, Setatsukinowa, Otsu, 520-2192, Japan, kinotake@belle.shiga-med.ac.jp.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  New Anticoagulants in Ischemic Heart Disease.
Next Document:  Multivessel Versus Culprit-Only Revascularization: One Time Versus Staged Procedures for the ACS Pop...