| Preservation of endothelium nitric oxide release by pulsatile flow cardiopulmonary bypass when compared with continuous flow. | |
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MedLine Citation:
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PMID: 19860792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this work is to analyze endothelium nitric oxide (NO) release in patients undergoing continuous or pulsatile flow cardiopulmonary bypass (CPB). Nine patients operated under continuous flow CPB, and nine patients on pulsatile flow CPB were enrolled. Plasma samples were withdrawn for the chemiluminescence detection of nitrite and nitrate. Moreover the cellular component was withdrawn for the detection of nitric oxide synthase (NOS) activity in the erythrocytes, and an estimation of systemic inflammatory response was carried out. Significant reduction in the intraoperative concentration with respect to the preoperative was observed only under continuous flow CPB for both nitrite and NO(x) (nitrite + nitrate) concentration (P = 0.010 and P = 0.016, respectively). Significant difference in intraoperative nitrite concentration was also observed between the groups (P = 0.012). Finally, erythrocytes showed a certain endothelial NOS activity, which did not differ between the groups, and no differences in the inflammatory response were pointed out. The significant reduction of NO(2)(-) concentration under continuous perfusion revealed the strong connection among perfusion modality, endothelial NO release, and plasmatic nitrite concentration. The similar erythrocyte eNOS activity between the groups revealed that the differences in blood NO metabolites are mainly ascribable to the endothelium release. |
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Authors:
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Ettore Lanzarone; Fabrizio Gelmini; Maddalena Tessari; Tiziano Menon; Hisanori Suzuki; Marina Carini; Maria Laura Costantino; Roberto Fumero; Giovanni Battista Luciani; Giuseppe Faggian |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-10-27 |
Journal Detail:
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Title: Artificial organs Volume: 33 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-12-21 Completed Date: 2010-03-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 926-34 Citation Subset: IM |
Affiliation:
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Laboratory of Mechanical Biological Structures, Department of Structural Engineering, Politecnico di Milano, Milan, Italy. ettore.lanzarone@polimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiopulmonary Bypass / instrumentation, methods* Endothelium / metabolism* Erythrocytes / enzymology Female Humans Male Middle Aged Nitrates / blood Nitric Oxide / metabolism* Nitric Oxide Synthase / metabolism Nitrites / blood Pulsatile Flow |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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