| Presentation and outcome of purpura fulminans associated with peripheral gangrene in 12 patients at Mayo Clinic. | |
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MedLine Citation:
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PMID: 17719676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dermatologists may be called to assist in the diagnosis and management of purpura fulminans. METHODS: This retrospective case series details the clinical presentation and outcomes of patients presenting with purpura fulminans associated with peripheral gangrene between 1989 and 2004. RESULTS: All 12 patients presented with sudden onset of purpuric patches and evolving gangrene of the extremities in association with a shock syndrome (hypotension, oliguria). Eleven patients had disseminated intravascular coagulation. The cause of purpura fulminans was infectious in 9 patients, surgical in two, and cancer in one. Three patients died (25%) within a week of onset of purpura fulminans. Of the 9 surviving patients, 8 required amputation of at least one limb. Four patients required amputation of all 4 limbs. LIMITATIONS: Retrospective study design, varying clinical descriptions, and potential referral bias are limitations. CONCLUSION: Purpura fulminans in association with symmetric peripheral gangrene is an ominous clinical presentation. |
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Authors:
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Mark D P Davis; Katrina M Dy; Steven Nelson |
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Publication Detail:
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Type: Case Reports; In Vitro; Journal Article; Review Date: 2007-08-24 |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: 57 ISSN: 1097-6787 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-20 Completed Date: 2007-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 944-56 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA. davis.mark2@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Amputation Child Child, Preschool Disseminated Intravascular Coagulation / etiology Fatal Outcome Female Gangrene / etiology* Humans Middle Aged Purpura, Schoenlein-Henoch / complications*, diagnosis, therapy Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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