Document Detail

Presentation and Outcomes for Children With Bone Marrow Necrosis and Acute Lymphoblastic Leukemia: A Literature Review.
MedLine Citation:
PMID:  21941136     Owner:  NLM     Status:  Publisher    
Bone marrow necrosis is a rare histopathology finding with the majority of cases occurring in the setting of a hematologic malignancy. This article reports a case of diffuse marrow necrosis in a child secondary to acute lymphoblastic leukemia and summarizes the clinical features and outcomes for children with bone marrow necrosis secondary to leukemia from 20 published reports. This review demonstrated that the most common presenting features were bone pain, fever, pancytopenia, and that outcomes were less favorable when compared with those without necrosis. However, contemporary literature suggests that outcomes are similar for children who have bone marrow necrosis secondary to leukemia when compared with overall survival rates for pediatric leukemia.
Nirmish R Shah; Daniel B Landi; Susan G Kreissman; Evan Kulbachi; Cassandra Moran
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Publication Detail:
Journal Detail:
Title:  Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology     Volume:  33     ISSN:  1536-3678     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-9-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  e316-e319     Citation Subset:  -    
Departments of *Pediatrics †Pathology ‡Duke Clinical Research Unit, Duke University Medical Center, Durham, NC.
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