Document Detail

Present status of drug resistance in cases of enteric fever in Rajasthan.
MedLine Citation:
PMID:  9251374     Owner:  NLM     Status:  MEDLINE    
Drug Sensitivity of Salmonella typhi isolated from 30 blood culture positive cases of typhoid fever who presented between Nov. '93 to Aug. '94 was tested to determine their in vitro susceptibility to various antimicrobiols. 56.6% showed resistance to chloramphenicol, 70% to amoxycillin, 50% to amikacin, 43.3% to gentamycin, 40% to ampicillin, 33.3% to cotrimoxazole, 30% to cephalexin and very low resistance (6.6% each) to ceftriaxone and cefotaxime. All the 30 cases were sensitive to ciprofloxacin and ofloxacin. 17 chloramphenicol resistant typhoid cases in whom chloramphenicol was initially started failed to respond to this drug even after 4-5 days therapy, indicating that in vivo response matched with the in vitro sensitivity. Clinical response to ciprofloxacin, whether given initially or following chloramphenicol failure was prompt and satisfactory. Ciprofloxacin thus appears to be a good choice in such cases.
V D Maheshwari; S K Agarwal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  44     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-08-29     Completed Date:  1997-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  618-9     Citation Subset:  IM    
Deptt. of Medicine, S.M.S. Medical College Jaipur (Raj.).
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MeSH Terms
Aminoglycosides / therapeutic use
Ampicillin Resistance*
Chloramphenicol Resistance*
Ciprofloxacin / therapeutic use
Drug Resistance, Multiple*
India / epidemiology
Microbial Sensitivity Tests
Salmonella typhi / drug effects*,  isolation & purification
Trimethoprim-Sulfamethoxazole Combination / therapeutic use
Typhoid Fever / drug therapy*,  epidemiology,  microbiology
Reg. No./Substance:
0/Aminoglycosides; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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