Document Detail


Present situation of biomarkers for copper status.
MedLine Citation:
PMID:  18779309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum or plasma copper and ceruloplasmin concentrations are the most widely used laboratory indicators to evaluate copper status. Both indicators are decreased in moderate or severe copper deficiency. The activity of several cuproenzymes is decreased in mild copper deficiency. However, their use is limited by the nonexistence of standardized assays and high interindividual variability and because some of these indicators are affected by other conditions. Recently, it was shown that the protein expression of the copper chaperone for superoxide dismutase (CCS) is increased in erythrocytes of rodents with mild copper deficiency. However, no traditional laboratory indicators have been identified as potential early markers of copper excess. It is possible that the biomarkers studied so far are not sensitive enough to detect an increase in body copper before the appearance of functional or clinical effects or that the homeostatic mechanisms are so strong that no significant changes in body copper occur with mild-to-moderate copper exposure. The identification of appropriate biomarkers for early detection of an increase in body copper represents a major challenge for further research, and the development of new approaches, such as network biology, allows us to search and propose new candidates to be studied. Recently, we found that CCS mRNA abundance in mononuclear blood cells significantly decreased after copper supplementation. The usefulness of this indicator to detect an increase in body copper should be assessed in clinical trials.
Authors:
Manuel Olivares; Marco A Méndez; Pablo A Astudillo; Fernando Pizarro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  88     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2008-10-09     Revised Date:  2009-05-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  859S-62S     Citation Subset:  AIM; IM    
Affiliation:
Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. molivare@inta.cl
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / metabolism*
Blood Proteins / metabolism
Ceruloplasmin / metabolism
Copper / deficiency,  metabolism*,  toxicity
Humans
Proteins / metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins; 0/Proteins; 7440-50-8/Copper; EC 1.16.3.1/Ceruloplasmin

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