Document Detail

Present significance of resistance to trimethoprim and sulphonamides in coliforms, Staphylococcus aureus, and Streptococcus faecalis.
MedLine Citation:
PMID:  4633678     Owner:  NLM     Status:  MEDLINE    
The incidence of trimethoprim resistance in coliforms and multiresistant strains of Staphylococcus aureus isolated in Bristol from 1970 to 1972 is low-2.3 and 1.0% respectively. The resistance is probably intrinsic; there is no evidence that it is R-factor or plasmid mediated. A single mechanism that confers resistance to both trimethoprim and sulphamethoxazole has not been detected. Normal growing one-step mutants of S. aureus and Escherichia coli resistant to trimethoprim could not be isolated in vitro. For these reasons cotrimoxazole should retain its usefulness against these bacteria for some years. However, contrimoxazole was found not to be bactericidal against many coliforms. The usefulness of cotrimoxazole against Streptococcus faecalis seems limited because mutants resistant to trimethoprim occurred at high frequency in one step.
E L Lewis; R W Lacey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  26     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1973 Mar 
Date Detail:
Created Date:  1973-06-25     Completed Date:  1973-06-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  AIM; IM    
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Chromosomes, Bacterial
Drug Resistance, Microbial*
Enterococcus faecalis / drug effects*
Escherichia coli / drug effects
Extracorporeal Circulation
Folic Acid Antagonists / pharmacology*
Genetics, Microbial
Microbial Sensitivity Tests
Pyrimidines / pharmacology*
Staphylococcus / drug effects*
Sulfamethoxazole / pharmacology
Sulfonamides / pharmacology*
Transduction, Genetic
Trimethoprim / pharmacology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Folic Acid Antagonists; 0/Pyrimidines; 0/Sulfonamides; 723-46-6/Sulfamethoxazole; 738-70-5/Trimethoprim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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