Document Detail

Present perspectives on cartilage and chondrocyte mechanobiology.
MedLine Citation:
PMID:  10912191     Owner:  NLM     Status:  MEDLINE    
The focus of work on mechanotransduction in cartilage has changed markedly over the last 10 years. At the beginning of the decade, the interest lay in determining the net response of cartilage plugs, almost always as 35S-sulphate or 3H-proline incorporation, to a variety of external loads, with the focus on whether changes in frequency in particular would stimulate or inhibit proteoglycan and protein synthesis [9,21]. Over the past few years the emphasis has shifted; it is now based mainly at the level of the cell as illustrated in Fig. 1. Here we will present a brief overview of the work presented at this symposium in light of these changes in approach.
J P Urban
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biorheology     Volume:  37     ISSN:  0006-355X     ISO Abbreviation:  Biorheology     Publication Date:  2000  
Date Detail:
Created Date:  2000-08-16     Completed Date:  2000-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372526     Medline TA:  Biorheology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  185-90     Citation Subset:  IM; S    
Physiology Laboratory, Oxford University, UK.
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MeSH Terms
Biocompatible Materials
Cartilage, Articular / physiology*
Cell Culture Techniques
Chondrocytes / physiology*
Hydrostatic Pressure
Osteoarthritis / therapy
Research Design
Signal Transduction / physiology*
Stress, Mechanical
Reg. No./Substance:
0/Biocompatible Materials

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