Document Detail


Present status of anticoagulation treatment in Japanese patients with atrial fibrillation: a report from the J-RHYTHM Registry.
MedLine Citation:
PMID:  21467664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Underuse and an inadequate range for the international normalized ratio (INR) for warfarin use are still problems in the management of the patients with atrial fibrillation (AF) in Japan.
METHODS AND RESULTS: From January to July 2009, a total of 7,937 AF patients [5,468 men (68.6 ± 10.0 years) and 2,469 women (72.2 ± 9.0 years)] were registered from 158 institutions for the J-RHYTHM Registry. Overall, 34.2% of the patients were over the age of 75. The associated cardiovascular diagnoses were hypertension in 59.1%, coronary artery disease in 10.1%, cardiomyopathy in 8.3%, valvular heart disease in 13.7% and artificial cardiac valves in 3.1% of the patients. The type of AF was paroxysmal in 37.1%, persistent in 14.4%, and permanent in 48.5%. Overall, 87.3% of patients were taking warfarin (2.9 ± 1.2mg/day), of whom 66.0% had an INR between 1.6 and 2.6, and 35.4% were in the INR range from 2.0 to 3.0 at the time of registration. Aspirin was prescribed in 22.3% of cases. The CHADS2 score was 0 in 15.7% of patients, 1 in 34.0%, and ≥ 2 in 50.3%.
CONCLUSIONS: At present, warfarin is used extensively in patients with AF whose stroke risk is relatively low (ie, in Japan) and half of them had CHADS2 scores of 0 to 1 (UMIN Clinical Trials Registry UMIN000001569).
Authors:
Hirotsugu Atarashi; Hiroshi Inoue; Ken Okumura; Takeshi Yamashita; Naoko Kumagai; Hideki Origasa;
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2011-04-05
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-26     Completed Date:  2011-09-16     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1328-33     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Nippon Medical School Tama-Nagayama Hospital, Tokyo, Japan. atarashi@nms.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Anticoagulants / therapeutic use*
Asian Continental Ancestry Group*
Aspirin / therapeutic use
Atrial Fibrillation / blood,  complications,  drug therapy*,  ethnology
Blood Coagulation / drug effects*
Chi-Square Distribution
Drug Monitoring / methods
Female
Fibrinolytic Agents / therapeutic use*
Guideline Adherence
Humans
International Normalized Ratio
Japan
Male
Middle Aged
Platelet Aggregation Inhibitors / therapeutic use
Practice Guidelines as Topic
Prospective Studies
Registries
Risk Assessment
Risk Factors
Stroke / blood,  ethnology,  etiology,  prevention & control*
Treatment Outcome
Warfarin / therapeutic use*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Fibrinolytic Agents; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 81-81-2/Warfarin
Investigator
Investigator/Affiliation:
H Inoue / ; K Okumura / ; H Atarashi / ; T Yamashita / ; M Sakurai / ; Y Kawamura / ; K Okumura / ; I Kubota / ; Y Kaneko / ; K Matumoto / ; S Ogawa / ; H Atarashi / ; T Yamashita / ; H Inoue / ; Y Aizawa / ; I Kodama / ; E Watanabe / ; Y Koretsune / ; Y Okuyama / ; A Shimizu / ; O Igawa / ; S Bando / ; M Fukatani / ; T Saikawa / ; A Chishaki / ; N Kumagai / ; H Origasa / ; N Kato / ; K Kanda / ; J Kato / ; H Obata / ; M Aoki / ; H Honda / ; Y Konta / ; T Hatayama / ; Y Abe / ; K Terata / ; T Yagi / ; A Ishida / ; T Komatsu / ; H Tachibana / ; H Suzuki / ; Y Kamiyama / ; T Watanabe / ; M Ogum / ; M Itoh / ; O Hirono / ; Y Tsunoda / ; K Ikeda / ; T Kanaya T / ; K Sakurai / ; H Sukekawa / ; S Nakada / ; T Itoh / ; S Tange / ; M Manita / ; M Ohta / ; H Eguma / ; R Kato / ; Y Endo / ; T Ogino / ; M Yamazaki / ; H Kanki / ; M Uchida / ; S Miyanaga / ; K Shibayama / ; N Toratani / ; T Kojima / ; M Ichikawa / ; M Saito / ; Y Umeda / ; T Sawanobori / ; H Sohara / ; S Okubo / ; T Okubo / ; T Tokunaga / ; O Kuboyama / ; H Ito / ; Y Kitahara / ; K Sagara / ; T Satoh / ; E Kodani / ; K Sugi / ; Y Kobayashi / ; Y Higashi / ; T Katoh / ; Y Hirayama / ; N Matsumoto / ; M Takano / ; T Ikeda / ; S Yusu / ; S Niwano / ; Y Nakazato / ; Y Kawano / ; M Sumiyoshi / ; N Hagiwara / ; K Murasaki / ; H Mitamura / ; S Nakagawa / ; K Okishige / ; K Azegami / ; H Aoyagi / ; K Sugiyama / ; M Nishizaki / ; N Yamawake / ; I Watanabe / ; K Ohkubo / ; H Sakurada / ; S Fukamizu / ; M Suzuki / ; W Nagahori / ; T Nakamura / ; Y Murakawa / ; N Hayami / ; K Yoshioka / ; M Amino / ; K Hirao / ; A Yagishita / ; K Ajiki / ; K Fujiu / ; Y Imai / ; A Yamashina / ; T Ishiyama / ; M Sakabe / ; K Nishida / ; H Asanoi / ; H Ueno / ; J-D Lee / ; Y Mitsuke / ; H Furushima / ; K Ebe / ; M Tagawa / ; M Sato / ; M Morikawa / ; K Yamashiro / ; K Takami / ; T Ozawa / ; M Watarai / ; M Yamauchi / ; H Kamiya / ; H Hirayama / ; Y Yoshida / ; T Murohara / ; Y Inden / ; H Osanai / ; N Ohte / ; T Goto / ; I Morishima / ; T Yamamoto / ; H Hayashi / ; T Urushida / ; Y Takada / ; R Kato / ; N Tsuboi / ; T Noda / ; T Hirose / ; H Izawa / ; A Sugiura / ; T Arakawa / ; K Kimura / ; T Mine / ; K Makita / ; H Shimizu / ; T Kurita / ; K Motoki / ; N Takeda / ; Y Kijima / ; M Ito / ; A Nakata / ; Y Ueda / ; A Hirata / ; S Kamakura / ; K Satomi / ; T Noda / ; Y Yamada / ; Y Yoshiga / ; H Ogawa / ; M Kimura / ; T Hayano / ; T Kinbara / ; H Tatsuno / ; M Harada / ; K F Kusano / ; M Adachi / ; A Yano / ; M Sawaguchi / ; J Yamasaki / ; T Matsuura / ; Y Tanaka / ; H Moritani / ; T Maki / ; S Okada / ; M Takechi / ; T Hamada / ; A Nishikado / ; Y Takagi / ; I Matsumoto / ; T Yamamoto / ; T Soeki / ; Y Doi / ; M Okawa / ; H Seo / ; S Kitamura / ; K Yamamoto / ; M Akizawa / ; N Kaname / ; S Ando / ; S Narita / ; T Nakamura / ; T Inou / ; Y Fukuizumi / ; K Saku / ; M Ogawa / ; Y Urabe / ; M Ikeuchi / ; S Harada / ; H Yamabe / ; Y Imamura / ; Y Yamanouchi / ; K Sadamatsu / ; K Yoshida / ; T Kubota / ; N Takahashi / ; N Makino / ; Y Higuchi / ; T Ooie / ; T Iwao / ; K Kitamura / ; T Imamura / ; K Maemura / ; N Komiya / ; M Hayano / ; H Yoshida / ; K Yamashiro / ; K Kumagai /
Comments/Corrections
Comment In:
Circ J. 2011;75(6):1314-5   [PMID:  21532184 ]

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